Yoav Sharoni, Emeritus

Our research aims to understand how dietary derived compounds (phytonutrients, mainly carotenoids and polyphenols) can affect human health. We study the effects of phytonutrients on various cellular activities of bone and skin cells, which may reverse the deterioration of these tissues due to exogenous and endogenous factors. We study bone cells under reduced gravity that causes degradation of the bone matrix and osteoporosis. We examine how phytonutrients can reduce the activity of osteoclasts, which degrade the bone, and improve the activity of osteoblasts, which build the bone. In skin cells, we try to prevent the deleterious effects of oxidative stress that can result from exogenous factors, such as UV and smoking or during aging. We examine the role of the combination of phytonutrients and estrogens in reducing oxidative stress and its negative effects by activating antioxidant defense mechanisms and modulating signaling pathways. The studies are conducted with the relevant cells in culture and a 3D bone model.

Email: yoav@bgu.ac.il