Assaf Rudich

The overarching focus in the lab is on elucidating mechanisms linking adipose tissue alterations with obesity-related increased risk for cardio-metabolic diseases. We hope to help obesity management become more personalized by exploiting cellular and biochemical features of adipose tissue. Specifically, we focus on the following questions: Which alterations in the cellular composition of adipose tissue affect cardiometabolic risk and can predict response to anti-obesity intervention? For this, we have recently established single-nucleus RNA sequencing of a human adipose tissue that enables us to detect not only cell types comprising adipose tissue but also to characterize subtypes of adipocytes. How does adipose tissue communicate with other tissues to generate homeostatic and pathogenic responses to excess calories? We particularly consider miRNAs and adipokines (established and novel adipose tissue hormones) as biomarkers and mediators. The lab is unique in utilizing a wide range of experimental approaches used in biomedical research, from the molecular/cellular level, via animal models, to analyses of human samples and clinical data.

Email: rudich@bgu.ac.il

Personal website: http://nibn.co.il/researcher/prof-assaf-rudich/