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Regenerative Medicine and Stem Cell (RMSC) Research Center
Regenerative Medicine and Stem Cell (RMSC) Research Center

Recent Selected Publications

  1. Chronic and acute exposure to rotenone reveals distinct Parkinson's disease-related phenotypes in human iPSC-derived peripheral neurons. Saleh MA, Amer-Sarsour F, Berant A, Pasmanik-Chor M, Kobo H, Sharabi Y, Vatine GD, Ashkenazi A. Free Radic Biol Med. 2024 Mar;213:164-173. doi: 10.1016/j.freeradbiomed.2024.01.016. Epub 2024 Jan 19. PMID: 38246514.

  2. Disease-associated polyalanine expansion mutations impair UBA6-dependent ubiquitination. Amer-Sarsour F, Falik D, Berdichevsky Y, Kordonsky A, Eid S, Rabinski T, Ishtayeh H, Cohen-Adiv S, Braverman I, Blumen SC, Laviv T, Prag G, Vatine GD, Ashkenazi A. EMBO J. 2024 Jan;43(2):250-276. doi: 10.1038/s44318-023-00018-9. Epub 2024 Jan 2. PMID: 38177505.

  3. Fluorescent proteins generate a genetic color polymorphism and counteract oxidative stress in intertidal sea anemones. Clarke DN, Rose NH, De Meulenaere E, Rosental B, Pearse JS, Pearse VB, Deheyn DD. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2317017121. doi: 10.1073/pnas.2317017121. Epub 2024 Mar 8. PMID: 38457522

  4. Engineered extracellular vesicle-mediated delivery of miR-199a-3p increases the viability of 3D-printed cardiac patches. Bar A, Kryukov O, Etzion S, Cohen S. Int J Bioprint. 2023 Jan 17;9(2):670. doi: 10.18063/ijb.v9i2.670. eCollection 2023. PMID: 37065655.

  5. Alginate sulfate-nanoparticles loaded with hepatocyte growth factor and insulin-like growth factor-1 improve left ventricular repair in a porcine model of myocardial ischemia reperfusion injury. Wu M, Pelacho B, Claus P, De Buck S, Veltman D, Gillijns H, Holemans P, Pokreisz P, Caluwé E, Iglesias Colino E, Cohen S, Prosper F, Janssens S. Eur J Pharm Biopharm. 2023 Mar;184:83-91. doi: 10.1016/j.ejpb.2023.01.012. Epub 2023 Jan 21. PMID: 36693545

  6. Potent inhibition of MMP-9 by a novel sustained-release platform attenuates left ventricular remodeling following myocardial infarction. Itzhar A, Yosef G, Eilon-Ashkenazy M, Shmidov Y, Gil H, Lacham-Hartman S, Elyagon S, Etzion S, Bitton R, Cohen S, Etzion Y, Papo N. J Control Release. 2023 Dec; 364:246-260. doi: 10.1016/j.jconrel.2023.10.033. Epub 2023 Oct 31. PMID: 37879441

  7. Editorial: Experimental models and model organisms in cardiac electrophysiology: opportunities and challenges. Brundel BJJM, Jopling C, Efimov IR, Charpentier F, Etzion Y. Front Physiol. 2023 Sep 6;14:1254596. doi: 10.3389/fphys.2023.1254596. eCollection 2023. PMID: 37745238 

  8. Functional defects in hiPSCs-derived cardiomyocytes from patients with a PLEKHM2 mutation associated with dilated cardiomyopathy and left ventricular non-compaction. Korover N, Etzion S, Cherniak A, Rabinski T, Levitas A, Etzion Y, Ofir R, Parvari R, Cohen S. Biol Res. 2023 Jun 23;56(1):34. doi: 10.1186/s40659-023-00442-5. PMID: 37349842  

  9. ZnT1 induces a crosstalk between T-type and L-type calcium channels through interactions with Raf-1 kinase and the calcium channel β2 subunit. Mor M, Beharier O, Cook DI, Campbell CR, Gheber LA, Katz A, Moran A, Etzion Y. Metallomics. 2023 Jun 1;15(6):mfad031. doi: 10.1093/mtomcs/mfad031. PMID: 37193665

  10. Cannabinoid receptor agonist attenuates angiotensin II-induced enlargement and mitochondrial dysfunction in rat atrial cardiomyocytes. Altieri DI, Etzion Y, Anderson HD. Front Pharmacol. 2023 Apr 11;14:1142583. doi: 10.3389/fphar.2023.1142583. eCollection 2023. PMID: 37113758 

  11. An objective tool for quantifying atrial fibrillation substrate in rats. Murninkas M, Gillis R, Elyagon S, Levi O, Mulla W, Katz A, Etzion Y, Gradwohl G. Am J Physiol Heart Circ Physiol. 2023 Apr 1;324(4):H461-H469. doi: 10.1152/ajpheart.00728.2022. Epub 2023 Feb 3. PMID: 36735403 

  12. Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutations. Hussein Y, Tripathi U, Choudhary A, Nayak R, Peles D, Rosh I, Rabinski T, Djamus J, Vatine GD, Spiegel R, Garin-Shkolnik T, Stern S. Transl Psychiatry. 2023 Jul 6;13(1):246. doi: 10.1038/s41398-023-02535-x. PMID: 37414777 

  13. Changes within the P681 residue of spike dictate cell fusion and syncytia formation of Delta and Omicron variants of SARS-CoV-2 with no effects on neutralization or infectivity. Kuzmina A, Korovin D, Cohen Lass I, Atari N, Ottolenghi A, Hu P, Mandelboim M, Rosental B, Rosenberg E, Diaz-Griffero F, Taube R. Heliyon. 2023 Jun;9(6):e16750. doi: 10.1016/j.heliyon.2023.e16750. Epub 2023 Jun 3. PMID: 37292300 

  14. Tryptophol Acetate and Tyrosol Acetate, Small-Molecule Metabolites Identified in a Probiotic Mixture, Inhibit Hyperinflammation. Malka O, Malishev R, Bersudsky M, Rajendran M, Krishnamohan M, Shaik J, Chamovitz DA, Tikhonov E, Sultan E, Koren O, Apte RN, Rosental B, Voronov E, Jelinek R. J Innate Immun. 2023;15(1):531-547. doi: 10.1159/000529782. Epub 2023 Feb 21. PMID: 36809756

  15. Three-Dimensional Bio-Printed Cardiac Patch for Sustained Delivery of Extracellular Vesicles from the Interface. Bar A, Kryukov O, Cohen S. Gels. 2022 Nov 25;8(12):769. doi: 10.3390/gels8120769. PMID: 36547293 

  16. Temporal Control over Macrophage Phenotype and the Host Response via Magnetically Actuated Scaffolds. Steele LA, Spiller KL, Cohen S, Rom S, Polyak B. ACS Biomater Sci Eng. 2022 Aug 8;8(8):3526-3541. doi: 10.1021/acsbiomaterials.2c00373. Epub 2022 Jul 15. PMID: 35838679

  17. Hypoxia-sensitive drug delivery to tumors. Filipczak N, Joshi U, Attia SA, Berger Fridman I, Cohen S, Konry T, Torchilin V. J Control Release. 2022 Jan;341:431-442. doi: 10.1016/j.jconrel.2021.11.034. Epub 2021 Nov 24. PMID: 34838607

  18. Defining the timeline of periostin upregulation in cardiac fibrosis following acute myocardial infarction in mice. Gil H, Goldshtein M, Etzion S, Elyagon S, Hadad U, Etzion Y, Cohen S. Sci Rep. 2022 Dec 18;12(1):21863. doi: 10.1038/s41598-022-26035-y. PMID: 36529756

  19. Incorrectly corrected? QT interval analysis in rats and mice. Mulla W, Murninkas M, Levi O,    Etzion Y. Front Physiol. 2022 Oct 11;13:1002203. doi: 10.3389/fphys.2022.1002203. eCollection 2022. PMID: 36304573. Review.

  20. Dock10 Regulates Cardiac Function under Neurohormonal Stress. Segal L, Etzion S, Elyagon S, Shahar M, Klapper-Goldstein H, Levitas A, Kapiloff MS, Parvari R, Etzion Y. Int J Mol Sci. 2022 Aug 25;23(17):9616. doi: 10.3390/ijms23179616. PMID: 36077014 

  21. Allosteric inhibitors targeting the calmodulin-PIP2 interface of SK4 K+ channels for atrial fibrillation treatment. Burg S, Shapiro S, Peretz A, Haimov E, Redko B, Yeheskel A, Simhaev L, Engel H, Raveh A, Ben-Bassat A, Murninkas M, Polak R, Haitin Y, Etzion Y, Attali B. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2202926119. doi: 10.1073/pnas.2202926119. Epub 2022 Aug 15. PMID: 35969786 

  22. PLEKHM2 Loss of Function Impairs the Activity of iPSC-Derived Neurons via Regulation of Autophagic Flux. Ben-Zvi H, Rabinski T, Ofir R, Cohen S, Vatine GD. Int J Mol Sci. 2022 Dec 17;23(24):16092. doi: 10.3390/ijms232416092. PMID: 36555735

  23. P450 oxidoreductase regulates barrier maturation by mediating retinoic acid metabolism in a model of the human BBB. Zlotnik D, Rabinski T, Halfon A, Anzi S, Plaschkes I, Benyamini H, Nevo Y, Gershoni OY, Rosental B, Hershkovitz E, Ben-Zvi A, Vatine GD. Stem Cell Reports. 2022 Sep 13;17(9):2050-2063. doi: 10.1016/j.stemcr.2022.07.010. Epub 2022 Aug 11. PMID: 35961311 

  24. SnapShot: Autonomic nervous system disorders. Sharabi Y, Vatine GD, Ashkenazi A. Neuron. 2022 Apr 20;110(8):1432-1432.e1. doi: 10.1016/j.neuron.2022.03.007. PMID: 35447099
     
  25. AAV9-MCT8 Delivery at Juvenile Stage Ameliorates Neurological and Behavioral Deficits in a Mouse Model of MCT8-Deficiency. Liao XH, Avalos P, Shelest O, Ofan R, Shilo M, Bresee C, Likhite S, Vit JP, Heuer H, Kaspar B, Meyer K, Dumitrescu AM, Refetoff S, Svendsen CN, Vatine GD. Thyroid. 2022 Jul;32(7):849-859. doi: 10.1089/thy.2022.0034. Epub 2022 May 20. PMID: 35350867 

  26. Heat stress increases immune cell function in Hexacorallia. Eliachar S, Snyder GA, Barkan SK, Talice S, Otolenghi A, Jaimes-Becerra A, Sharoni T, Sultan E, Hadad U, Levy O, Moran Y, Gershoni-Yahalom O, Traylor-Knowles N, Rosental B. Front Immunol. 2022 Dec 22;13:1016097. doi: 10.3389/fimmu.2022.1016097. eCollection 2022. PMID: 36618389 

  27. Heterologous reporter expression in the planarian Schmidtea mediterranea through somatic mRNA transfection. Hall RN, Weill U, Drees L, Leal-Ortiz S, Li H, Khariton M, Chai C, Xue Y, Rosental B, Quake SR, Sánchez Alvarado A, Melosh NA, Fire AZ, Rink JC, Wang B. Cell Rep Methods. 2022 Sep 20;2(10):100298. doi: 10.1016/j.crmeth.2022.100298. eCollection 2022 Oct 24. PMID: 36313809 

  28. Editorial: Innate Immunity in Early Diverging Metazoans. Traylor-Knowles N, Browne WE, Mydlarz LD, Palmer CV, Rosental B. Front Immunol. 2022 Jan 31;13:816550. doi: 10.3389/fimmu.2022.816550. eCollection 2022. PMID: 35173730. 

  29. High-throughput microfluidic 3D biomimetic model enabling quantitative description of the human breast tumor microenvironment. Berger Fridman I, Kostas J, Gregus M, Ray S, Sullivan MR, Ivanov AR, Cohen S, Konry T. Acta Biomater. 2021 Sep 15;132:473-488. doi: 10.1016/j.actbio.2021.06.025. Epub 2021 Jun 18. PMID: 34153511 

  30. Generation and characterization of three human induced pluripotent stem cell lines (iPSC) from two family members with dilated cardiomyopathy and left ventricular noncompaction (DCM-LVNC) and one healthy heterozygote sibling. Ben-Zvi H, Korover N, Rabinski T, Ofir R, Cohen S. Stem Cell Res. 2021 May;53:102382. doi: 10.1016/j.scr.2021.102382. Epub 2021 May 5. PMID: 34088011 

  31. High throughput microfluidic system with multiple oxygen levels for the study of hypoxia in tumor spheroids. Berger Fridman I, Ugolini GS, VanDelinder V, Cohen S, Konry T. Biofabrication. 2021 Apr 26;13(3). doi: 10.1088/1758-5090/abdb88. PMID: 33440359

  32. The Effect of Sera from Children with Obstructive Sleep Apnea Syndrome (OSAS) on Human Cardiomyocytes Differentiated from Human Embryonic Stem Cells. Haddad H, Etzion S, Rabinski T, Ofir R, Regev D, Etzion Y, Gopas J, Goldbart A. Int J Mol Sci. 2021 Oct 22;22(21):11418. doi: 10.3390/ijms222111418. PMID: 34768848 

  33. Recapitulation of dyssynchrony-associated contractile impairment in asymmetrically paced engineered heart tissue. Stenzig J, Lemoine MD, Stoter AMS, Wrona KM, Lemme M, Mulla W, Etzion Y, Eschenhagen T, Hirt MN. J Mol Cell Cardiol. 2022 Feb;163:97-105. doi: 10.1016/j.yjmcc.2021.10.001. Epub 2021 Oct 8. PMID: 34634355 

  34. Cannabinoid Receptor Agonist Inhibits Atrial Electrical Remodeling in a Tachypaced Ex Vivo Rat Model. Lee DI, Murninkas M, Elyagon S, Etzion Y, Anderson HD. Front Pharmacol. 2021 Apr 22;12:642398. doi: 10.3389/fphar.2021.642398. eCollection 2021. PMID: 33967775 

  35. Parkinson's disease outside the brain: targeting the autonomic nervous system. Sharabi Y, Vatine GD, Ashkenazi A. Lancet Neurol. 2021 Oct;20(10):868-876. doi: 10.1016/S1474-4422(21)00219-2. PMID: 34536407 Review.

  36. Induced pluripotent stem cell (iPSC) lines from two individuals carrying a homozygous (BGUi007-A) and a heterozygous (BGUi006-A) mutation in ELP1 for in vitro modeling of familial dysautonomia. Dor L, Rabinski T, Zlotnik D, Shilian M, Weil M, Vatine GD. Stem Cell Res. 2021 Aug;55:102495. doi: 10.1016/j.scr.2021.102495. Epub 2021 Aug 11. PMID: 34419746 

  37. Introducing ADNP and SIRT1 as new partners regulating microtubules and histone methylation. Hadar A, Kapitansky O, Ganaiem M, Sragovich S, Lobyntseva A, Giladi E, Yeheskel A, Avitan A, Vatine GD, Gurwitz D, Ivashko-Pachima Y, Gozes I. Mol Psychiatry. 2021 Nov;26(11):6550-6561. doi: 10.1038/s41380-021-01143-9. Epub 2021 May 10. PMID: 33967268

  38. Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane. Vatine GD, Shelest O, Barriga BK, Ofan R, Rabinski T, Mattis VB, Heuer H, Svendsen CN. Glia. 2021 Sep;69(9):2146-2159. doi: 10.1002/glia.24014. Epub 2021 May 6. PMID: 33956384

  39. Reprogramming of two induced pluripotent stem cell lines from a heterozygous GRIN2D developmental and epileptic encephalopathy (DEE) patient (BGUi011-A) and from a healthy family relative (BGUi012-A). Rabinski T, Sagiv ST, Hausman-Kedem M, Fattal-Valevski A, Rubinstein M, Avraham KB, Vatine GD. Stem Cell Res. 2021 Mar;51:102178. doi: 10.1016/j.scr.2021.102178. Epub 2021 Jan 15. PMID: 33482465 

  40. SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera. Kuzmina A, Wattad S, Khalaila Y, Ottolenghi A, Rosental B, Engel S, Rosenberg E, Taube R. iScience. 2021 Dec 17;24(12):103467. doi: 10.1016/j.isci.2021.103467. Epub 2021 Nov 15. PMID: 34805783 

  41. Evolution of Cellular Immunity Effector Cells; Perspective on Cytotoxic and Phagocytic Cellular Lineages. Mandujano-Tinoco EA, Sultan E, Ottolenghi A, Gershoni-Yahalom O, Rosental B. Cells. 2021 Jul 22;10(8):1853. doi: 10.3390/cells10081853. PMID: 34440622. Review.

  42. Botryllus schlosseri as a Unique Colonial Chordate Model for the Study and Modulation of Innate Immune Activity. Goldstein O, Mandujano-Tinoco EA, Levy T, Talice S, Raveh T, Gershoni-Yahalom O, Voskoboynik A, Rosental B. Mar Drugs. 2021 Aug 9;19(8):454. doi: 10.3390/md19080454. PMID: 34436293. Review.

  43. Functional Characterization of Hexacorallia Phagocytic Cells. Snyder GA, Eliachar S, Connelly MT, Talice S, Hadad U, Gershoni-Yahalom O, Browne WE, Palmer CV, Rosental B, Traylor-Knowles N. Front Immunol. 2021 Jul 26;12:662803. doi: 10.3389/fimmu.2021.662803. eCollection 2021. PMID: 34381444 

  44. Stem Cells and Innate Immunity in Aquatic Invertebrates: Bridging Two Seemingly Disparate Disciplines for New Discoveries in Biology. Ballarin L, Karahan A, Salvetti A, Rossi L, Manni L, Rinkevich B, Rosner A, Voskoboynik A, Rosental B, Canesi L, Anselmi C, Pinsino A, Tohumcu BE, Jemec Kokalj A, Dolar A, Novak S, Sugni M, Corsi I, Drobne D. Front Immunol. 2021 Jun 30;12:688106. doi: 10.3389/fimmu.2021.688106. eCollection 2021. PMID: 34276677 

  45. Combining CD47 blockade with trastuzumab eliminates HER2-positive breast cancer cells and overcomes trastuzumab tolerance. Upton R, Banuelos A, Feng D, Biswas T, Kao K, McKenna K, Willingham S, Ho PY, Rosental B, Tal MC, Raveh T, Volkmer JP, Pegram MD, Weissman IL. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2026849118. doi: 10.1073/pnas.2026849118. PMID: 34257155 

  46. The Diverse Transformer (Trf) Protein Family in the Sea Urchin Paracentrotus lividus Acts through a Collaboration between Cellular and Humoral Immune Effector Arms. Yakovenko I, Donnyo A, Ioscovich O, Rosental B, Oren M. Int J Mol Sci. 2021 Jun 22;22(13):6639. doi: 10.3390/ijms22136639. PMID: 34206148.

  47. A new implantable tool for repeated assessment of supraventricular electrophysiology and atrial fibrillation susceptibility in freely moving rats. Murninkas M, Gillis R, Lee DI, Elyagon S, Bhandarkar NS, Levi O, Polak R, Klapper-Goldstein H, Mulla W, Etzion Y. Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H713-H724. doi: 10.1152/ajpheart.00676.2020. Epub 2020 Dec 18. PMID: 33337966 ​ 

  48. VDAC1 in the diseased myocardium and the effect of VDAC1-interacting compound on atrial fibrosis induced by hyperaldosteronism. Klapper-Goldstein H, Verma A, Elyagon S, Gillis R, Murninkas M, Pittala S, Paul A, Shoshan-Barmatz V, Etzion Y. Sci Rep. 2020 Dec 16;10(1):22101. doi: 10.1038/s41598-020-79056-w. PMID: 33328613.

  49. Duchenne Muscular Dystrophy and Early Onset Hypertrophic Cardiomyopathy associated with Mutations in Dystrophin and Hypertrophic Cardiomyopathy-Associated Genes. Aspit L, Arwas N, Krymko H, Etzion Y, Parvari R, Levitas A. J Pediatr Genet. 2020 Nov 19;11(4):304-308. doi: 10.1055/s-0040-1718724. eCollection 2022 Dec. PMID: 36267863.

  50. A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy. Levitas A, Muhammad E, Zhang Y, Perea Gil I, Serrano R, Diaz N, Arafat M, Gavidia AA, Kapiloff MS, Mercola M, Etzion Y, Parvari R, Karakikes I. PLoS Genet. 2020 Sep 14;16(9):e1009000. doi: 10.1371/journal.pgen.1009000. eCollection 2020 Sep. PMID: 32925938 

  51. Generation of iPSC lines from two (BGUi002-A and BGUi003-A) homozygous p450 oxidoreductase-deficient patients and from one (BGUi001-A) heterozygous healthy family relative. Zlotnik D, Rabinski T, Ofir R, Hershkovitz E, Vatine GD. Stem Cell Res. 2020 Oct;48:101975. doi: 10.1016/j.scr.2020.101975. Epub 2020 Sep 1. PMID: 32905996 

  52. Generation and characterization of iPSC lines (BGUi004-A, BGUi005-A) from two identical twins with polyalanine expansion in the paired-like homeobox 2B (PHOX2B) gene. Falik D, Rabinski T, Zlotnik D, Eshel R, Zorsky M, Garin-Shkolnik T, Ofir R, Adato A, Ashkenazi A, Vatine GD. Stem Cell Res. 2020 Oct;48:101955. doi: 10.1016/j.scr.2020.101955. Epub 2020 Aug 14. PMID: 32822965

  53. Sexual and asexual development: two distinct programs producing the same tunicate. Kowarsky M, Anselmi C, Hotta K, Burighel P, Zaniolo G, Caicci F, Rosental B, Neff NF, Ishizuka KJ, Palmeri KJ, Okamoto J, Gordon T, Weissman IL, Quake SR, Manni L, Voskoboynik A. Cell Rep. 2021 Jan 26;34(4):108681. doi: 10.1016/j.celrep.2020.108681. PMID: 33503429 

  54. Fluorescence-Activated Cell Sorting for the Isolation of Scleractinian Cell Populations. Snyder GA, Browne WE, Traylor-Knowles N, Rosental B. J Vis Exp. 2020 May 31;(159). doi: 10.3791/60446. PMID: 32538898​

  55. Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD. Drakulic D, Djurovic S, Syed YA, Trattaro S, Caporale N, Falk A, Ofir R, Heine VM, Chawner SJRA, Rodriguez-Moreno A, van den Bree MBM, Testa G, Petrakis S, Harwood AJ. Mol Autism. 2020 Jun 1;11(1):42. doi: 10.1186/s13229-020-00343-4. PMID: 32487215 Free article. Review​

  56. Generation of a Human iPSC-Based Blood-Brain Barrier Chip. Jagadeesan S, Workman MJ, Herland A, Svendsen CN, Vatine GD. J Vis Exp. 2020 Mar 2;(157). doi: 10.3791/60925. PMID: 32176199​

  57. Evolutionary perspective on the hematopoietic system through a colonial chordate: allogeneic immunity and hematopoiesis. Rosental B, Raveh T, Voskoboynik A, Weissman IL. Curr Opin Immunol. 2020 Feb;62:91-98. doi: 10.1016/j.coi.2019.12.006. PMID: 31954962 Review.

  58. Inducing Endogenous Cardiac Regeneration: Can Biomaterials Connect the Dots? Bar A, Cohen S. Front Bioeng Biotechnol. 2020 Feb 27;8:126. doi: 10.3389/fbioe.2020.00126. eCollection 2020. PMID: 32175315 Free PMC article. Review.

  59. An implantable system for long-term assessment of atrial fibrillation substrate in unanesthetized rats exposed to underlying pathological conditions. Klapper-Goldstein H, Murninkas M, Gillis R, Mulla W, Levanon E, Elyagon S, Schuster R, Danan D, Cohen H, Etzion Y. Sci Rep. 2020 Jan 17;10(1):553. doi: 10.1038/s41598-020-57528-3. PMID: 31953473 Free PMC article.

  60. MiR-499 Responsive Lethal Construct for Removal of Human Embryonic Stem Cells after Cardiac Differentiation. Elovic E, Etzion S, Cohen S. Sci Rep. 2019 Oct 10;9(1):14490. doi: 10.1038/s41598-019-50899-2. PMID: 31601830 Free PMC article.

  61. Corrigendum to: A new cis-acting regulatory element driving gene expression in the zebrafish pineal gland. Alon S, Eisenberg E, Jacob-Hirsch J, Rechavi G, Vatine G, Toyama R, Coon SL, Klein DC, Gothilf Y. Bioinformatics. 2019 Oct 15;35(20):4206. doi: 10.1093/bioinformatics/btz410. PMID: 31102508 Free PMC article

  62. Rapid Atrial Pacing Promotes Atrial Fibrillation Substrate in Unanesthetized Instrumented Rats. Mulla W, Hajaj B, Elyagon S, Mor M, Gillis R, Murninkas M, Klapper-Goldstein H, Plaschkes I, Chalifa-Caspi V, Etzion S, Etzion Y. Front Physiol. 2019 Sep 20;10:1218. doi: 10.3389/fphys.2019.01218. eCollection 2019.

  63. Letter by Mulla and Etzion Regarding Article, "Chronic Atrial and Ventricular Pacing in the Mouse: Application to Model Cardiac Dyssynchrony and Resynchronization in Heart Failure".Mulla W, Etzion Y. Circ Heart Fail. 2019 May;12(5):e006083. doi: 10.1161/CIRCHEARTFAILURE.119.006083. PMID: 31079490

  64. CAP2 mutation leads to impaired actin dynamics and associates with supraventricular tachycardia and dilated cardiomyopathy. Aspit L, Levitas A, Etzion S, Krymko H, Slanovic L, Zarivach R, Etzion Y, Parvari R. J Med Genet. 2019 Apr;56(4):228-235. doi: 10.1136/jmedgenet-2018-105498. Epub 2018 Dec 5. PMID: 30518548

  65. Co-assembled Ca2+ Alginate-Sulfate Nanoparticles for Intracellular Plasmid DNA Delivery. Goldshtein M, Shamir S, Vinogradov E, Monsonego A, Cohen S. Mol Ther Nucleic Acids. 2019 Jun 7;16:378-390. doi: 10.1016/j.omtn.2019.03.006. Epub 2019 Mar 28. PMID: 31003172 Free PMC article.

  66. Reconstruction of the ovary microenvironment utilizing macroporous scaffold with affinity-bound growth factors. Felder S, Masasa H, Orenbuch A, Levaot N, Shachar Goldenberg M, Cohen S. Biomaterials. 2019 Jun;205:11-22. doi: 10.1016/j.biomaterials.2019.03.013. Epub 2019 Mar 14. PMID: 30901634

  67. Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications. Vatine GD, Barrile R, Workman MJ, Sances S, Barriga BK, Rahnama M, Barthakur S, Kasendra M, Lucchesi C, Kerns J, Wen N, Spivia WR, Chen Z, Van Eyk J, Svendsen CN. Cell Stem Cell. 2019 Jun 6;24(6):995-1005.e6. doi: 10.1016/j.stem.2019.05.011. PMID: 31173718

  68. Nanoparticle Delivery of miRNA-21 Mimic to Cardiac Macrophages Improves Myocardial Remodeling after Myocardial Infarction. Bejerano T, Etzion S, Elyagon S, Etzion Y, Cohen S. Nano Lett. 2018 Sep 12;18(9):5885-5891. doi: 10.1021/acs.nanolett.8b02578. Epub 2018 Aug 29. PMID: 30141949

  69. Articular cartilage regeneration using acellular bioactive affinity-binding alginate hydrogel: A 6-month study in a mini-pig model of osteochondral defects. Ruvinov E, Tavor Re'em T, Witte F, Cohen S. J Orthop Translat. 2018 Sep 9;16:40-52. doi: 10.1016/j.jot.2018.08.003. eCollection 2019 Jan. PMID: 30723680

  70. Nocturnal Atrial Fibrillation Caused by Mutation in KCND2, Encoding Pore-Forming (α) Subunit of the Cardiac Kv4.2 Potassium Channel. Drabkin M, Zilberberg N, Menahem S, Mulla W, Halperin D, Yogev Y, Wormser O, Perez Y, Kadir R, Etzion Y, Katz A, Birk OS. Circ Genom Precis Med. 2018 Nov;11(11):e002293. doi: 10.1161/CIRCGEN.118.002293. PMID: 30571183 Clinical Trial.

  71. Magnetic Induction of Multiscale Anisotropy in Macroporous Alginate Scaffolds. Margolis G, Polyak B, Cohen S. Nano Lett. 2018 Nov 14;18(11):7314-7322. doi: 10.1021/acs.nanolett.8b03514. Epub 2018 Nov 5. PMID: 30380888

  72. Live imaging flow bioreactor for the simulation of articular cartilage regeneration after treatment with bioactive hydrogel. Bar A, Ruvinov E, Cohen S. Biotechnol Bioeng. 2018 Sep;115(9):2205-2216. doi: 10.1002/bit.26736. Epub 2018 Jun 25. PMID: 29873069

  73. Unanesthetized Rodents Demonstrate Insensitivity of QT Interval and Ventricular Refractory Period to Pacing Cycle Length. Mulla W, Gillis R, Murninkas M, Klapper-Goldstein H, Gabay H, Mor M, Elyagon S, Liel-Cohen N, Bernus O, Etzion Y.Front Physiol. 2018 Jul 11;9:897. doi: 10.3389/fphys.2018.00897. eCollection 2018. PMID: 30050462

  74. Asteriscus graveolens Extract in Combination with Cisplatin/Etoposide/Doxorubicin Suppresses Lymphoma Cell Growth through Induction of Caspase-3 Dependent Apoptosis. Tayeh Z, Ofir R. Int J Mol Sci. 2018 Jul 30;19(8):2219. doi: 10.3390/ijms19082219. PMID: 30061495

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  80. Periostin in cardiovascular disease and development: a tale of two distinct roles. Landry NM, Cohen S, Dixon IM. Basic Res Cardiol. 2018, 113(1):1. doi: 10.1007/s00395-017-0659-5.

  81. Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats. Mulla W, Etzion S, Elyagon S, Gillis R, Murninkas M, Konstantino Y, Mannhardt I, Eschenhagen T, Liel-Cohen N & Etzion Y, Sci. Rep. 2017 Jul 19;7(1):5931. doi: 10.1038/s41598-017-06197-w.

  82. Mapping Whole-Transcriptome Splicing in Mouse Hematopoietic Stem Cells. Goldstein O, Meyer K, Greenshpan Y, Bujanover N, Feigin M, Ner-Gaon H, Shay T, Gazit R. Stem Cell Reports. 2017 Jan 10; 8(1):163-176.

  83. A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans. Bar-Lavan Y, Shemesh N, Dror S, Ofir R, Yeger Lotem E, Ben-Zvi A. PLoS Genet. 2016 Dec 30;12(12).

  84. TGF-β affinity-bound to a macroporous alginate scaffold generates local and peripheral immunotolerant responses and improves allocell transplantation.

  85. Orr S, Strominger I, Eremenko E, Vinogradov E, Ruvinov E, Monsonego A, Cohen S. Acta Biomater. 2016 Nov;45:196-209. 10.1016/j.actbio.2016.08.015.  Epub 2016 Aug 11.

  86. Feasibility of Leadless Cardiac Pacing Using Injectable Magnetic Microparticles. Rotenberg MY, Gabay H, Etzion Y, Cohen S. Sci Rep. 2016 Apr 19;6:24635. doi: 10.1038/srep24635.

  87. Spontaneous Coassembly of Biologically Active Nanoparticles via Affinity Binding of Heparin-Binding Proteins to Alginate-Sulfate.   Ruvinov E, Freeman I, Fredo R, Cohen S. Nano Lett. 2016 Feb 10;16(2):883-8.

  88. PLEKHM2 mutation leads to abnormal localization of lysosomes, impaired autophagy flux and associates with recessive dilated cardiomyopathy and left ventricular noncompaction. Muhammad E, Levitas A, Singh SR, Braiman A, Ofir R, Etzion S, Sheffield VC, Etzion Y, Carrier L, Parvari R. Hum Mol Genet. 2015 Dec 20;24(25):7227-40.

  89. D117N in Cypher/ZASP may not be a causative mutation for dilated cardiomyopathy and ventricular arrhythmias. Levitas A, Konstantino Y, Muhammad E, Afawi Z, Marc Weinstein J, Amit G, Etzion Y, Parvari R.Eur J Hum Genet. 2016 May;24(5):666-71.

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