Jacob Gopas, Emeritus

Three main projects are undertaken in the laboratory: 1. The development
of anti-inflammatory and anti-pathogen natural compounds (against
Leishmania, malaria, and quorum sensing/biofilm-forming bacteria). One
such compound, Nupharidine, derived from the water lily (Nuphar lutea)
and PL-18, a synthetic derivative from pepper (piperlongumine), are
respectively being pursued. 2. The study of the pathobiology of Hodgkin’s
lymphoma, especially the presence of senescence cells in tumor biopsies
and cell lines, as well as platinum drug resistance mechanisms of ovarian
carcinoma cells. 3. Human cardiomyocytes derived from pluripotent stem
cells pathology features due to hypoxia as a model of obstructive sleep
apnea.

Contact: Jacob@bgu.ac.il