Yifat Miller
Senior Academic
A zinc-dependent switching mechanism from an open to a new closed-state conformation of insulin-degrading enzyme
The switching mechanism between an open-state conformation and a newly closed-state conformation of IDE is stabilized by electrostatic interactions between domain D1 and domain D3. The loss of a Zn2+ ion at the catalytic zinc-binding site in the open-state conformation of IDE prevents the transition to the closed-state conformation.
| Publication language | English |
| Pages | 3205-3209 |
| Journal | Inorganic Chemistry Frontiers |
| Volume | 8 |
| Issue number | 13 |
| Publication status | Published - 07.07.2021 |
ASJC Scopus subject areas
Inorganic Chemistry
