Ilya Fleidervish

Publications (selected):

• Fleidervish, I.A., Libman, L., Katz, E. & Gutnick, M.J. (2008) Endogenous polyamines regulate cortical neuronal excitability by blocking voltage-gated na+ channels. Proc Natl Acad Sci U S A 105, 18994-18999.
• Fleidervish, I.A., Lasser-Ross, N., Gutnick, M.J. & Ross, W.N. (2010) Na+ imaging reveals little difference in action potential-evoked na+ influx between axon and soma. Nat Neurosci 13, 852-860.
• Baranauskas, G., David, Y. & Fleidervish, I.A. (2013) Spatial mismatch between the na+ flux and spike initiation in axon initial segment. Proc Natl Acad Sci U S A 110, 4051-4056.
• Lezmy, J., Lipinsky, M., Khrapunsky, Y., Patrich, E., Shalom, L., Peretz, A., Fleidervish, I.A. & Atali, B. (2017) M-current inhibition rapidly induces a unique ck2-dependent plasticity of the axon initial segment. Proc Natl Acad Sci U S A 114, E10234-E10243.
• Tkatch, T., Greotti, E., Baranauskas, G., Pendin, D., Roy, S., Nita, L.I., Wettmarshausen, J., Prigge, M., Yizhar, O., Shirihai, O.S., Fishman, D., Hershfinkel, M., Fleidervish, I.A., Perocchi, F., Pozzan, T. & Sekler, I. (2017) Optogenetic control of mitochondrial metabolism and ca(2+) signaling by mitochondria-targeted opsins. Proc Natl Acad Sci U S A 114, E5167-E5176.
• Katz, E., Stoler, O., Scheller, A., Khrapunsky, Y., Goebbels, S., Kirchhoff, F., Gutnick, M.J., Wolf, F. & Fleidervish, I.A. (2018) Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons. Proc Natl Acad Sci U S A 115, E7184-E7192.
• Revah, O., Stoler, O., Neef, A., Wolf, F., Fleidervish, I.A. & Gutnick, M.J. (2019) Dynamic gain analysis reveals encoding deficiencies in cortical neurons that recover from hypoxia-induced spreading depolarizations. J Neurosci 39, 7790-7800.
• Shvartsman, A., Kotler, O., Stoler, O., Khrapunsky, Y., Melamed, I. & Fleidervish, I.A. (2021) Subcellular distribution of persistent sodium conductance in cortical pyramidal neurons. J Neurosci 41, 6190-6201.
• Stoler, O., Stavsky, A., Khrapunsky, Y., Melamed, I., Stutzmann, G., Gitler, D., Sekler, I. & Fleidervish, I. (2022) Frequency- and spike-timing-dependent mitochondrial ca(2+) signaling regulates the metabolic rate and synaptic efficacy in cortical neurons. Elife 11.
• Kotler, O., Gutnick, M.J. & Fleidervish, I.A. (2022) In computational models, action potential propagation in ultrathin axons is resilient despite considerable intracellular Na⁺  accumulation. Proc Natl Acad Sci U S A 119, e2120782119.
• Kotler, O., Khrapunsky, Y., Shvartsman, A., Dai, H., Plant, L.D., Goldstein, S.A.N. & Fleidervish, I. (2023) Sumoylation of Na(v)1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons. Elife 12.
• Kotler, O., Miyazaki, K., Khrapunsky, Y., Ross, W.N. & Fleidervish, I.A. (2025) Nodal Na⁺ and Ca²⁺ flux dynamics in cortical myelinated axons. Front Cell Neurosci 19.
• Kotler, O., Khrapunsky, Y., Melamed, I., Peles, E., Ross, W.N. & Fleidervish, I. (2026) Cortical gray matter myelin cuts energy cost of spike propagation without increasing conduction velocity. Proc Natl Acad Sci U S A, in press