Alon Monsonego
Senior Academic
Bone-marrow Stromal Cells Exert Immunosuppressive Effects on Immune Cells Co-cultivated in 3D Alginate Scaffolds
Stromal cells have been shown to exert a potent immunosuppressive effect on immune cells when co-cultivated on flat two-dimensional (2D) dishes1 . Yet, 2D cell cultivation may not reliably represent cell function in a physiological setting.
In this work we investigated whether stromal cells would exert immunosuppression on bone marrow derived dendritic cells (BMDC) and T cells, when co-cultured within 3D porous alginate scaffolds2 . Alginate scaffolds herein are replacing the extracellular matrix (ECM), providing both a physical support and biological
cues for the seeded cells and closing the gap to in vivo conditions.
In this work we investigated whether stromal cells would exert immunosuppression on bone marrow derived dendritic cells (BMDC) and T cells, when co-cultured within 3D porous alginate scaffolds2 . Alginate scaffolds herein are replacing the extracellular matrix (ECM), providing both a physical support and biological
cues for the seeded cells and closing the gap to in vivo conditions.
| Publication language | English |
| Pages | S114-S114 |
| Volume | 131 |
| Publication status | Published - 2009 |
