Various age-related diseases such as dementia, cancer, diabetes, and heart diseases are characterized by declined repair along with dysregulated inflammation. Our studies reveal trajectories of immune system aging which contribute to changes in the immune ecosystem and thereby manifested either as healthy aging or accumulated tissue damage and various pathologies.

Although the etiology of autoimmune diseases is mostly unknown, it is becoming clear that a loss in immune regulation results in pathogenic stimulation of autoreactive lymphocytes which otherwise kept quiescent. Once such pathogenic stimulation of lymphocytes occurs, the cells can renew and continuously attack the body. Our research, in collaboration with Prof. Smadar Cohen, is aimed at generating transplantable lymphoid-like scaffolds which attenuate the function of pathogenic T cells and hence allow to preserve essential tissue functions.