Nanomaterials @ Interfaces Research Group

Prof. Yuval Golan's Research Group

One-Pot Hydrothermal Synthesis of Elements (B, N, P)-Doped Fluorescent Carbon Dots for Cell Labelling, Differentiation and Outgrowth of Neuronal Cells

Vijay B. Kumar, Raj Kumar, Ofir Friedman, Yuval Golan, Aharon Gedanken, Orit Shefi

Here, we report the use of the chemically modified one-step facile hydrothermal process to develop Boron (B), Nitrogen (N), and Phosphorous (P) doped carbon dots (E@CDs). The chemical characterization of the E@CDs was systematically studied by several analytical techniques that confer doping of elements by known characteristics. The obtained E@CDs had observed very homogeneous size distribution and displayed excitation dependent fluorescence properties, and high quantum yield (QY) was measured in case of B and N doping. Excellent cell viability and good cellular uptake was observed for all E@CDs. Finally, E@CDs were compared with pristine CDs on their effect on cell labelling, neural differentiation process and outgrowth of neurite network. By manipulating the doping of CDs, we can control the branching pattern and outgrowth of neuronal developments. The E@CDs are capable due to their photostability biocompatibility, and possible selective affinity towards nanomedicine applications.

Publication language English
Pages 4222-4232
Journal ChemistrySelect
Volume 4
Issue number 14
Publication status Published - 16.04.2019

Keywords

Doped carbon dots
Fluorescence
Hydrothermal process
Nanoparticle
Neural outgrowth
Neural tissue engineering

ASJC Scopus subject areas

General Chemistry
Access to Document
10.1002/slct.201900581
Other files and links
Link to publication in Scopus