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Selection advantage of metabolic over non-metabolic replicators

A kinetic analysis

Nathaniel Wagner, Addy Pross,Emmanuel Tannenbaum

A kinetic analysis and simulation of the replication reactions of two competing replicators-one non-metabolic (thermodynamic), the other metabolic, are presented. Our analysis indicates that in a rich resource environment the non-metabolic replicator is likely to be kinetically selected for over the metabolic replicator. However, in the more typical resource-poor environment it will be the metabolic replicator that is the kinetically more stable entity, and the one that will be kinetically selected for. Accordingly, a causal relationship between the emergence of a simple replicator and the emergence of a metabolic system is indicated. The results lend further support for the "replication first" school of thought in the origin of life problem by providing a mechanistic basis for the emergence of a metabolism, once a simple non-metabolic replicating system has itself been established. The study reaffirms our view that the roots of Darwinian theory may be found within standard chemical kinetic theory.

Publication language English
Pages 126-129
Journal BioSystems
Volume 99
Issue number 2
Publication status Published - 01.01.2010

Keywords

Metabolism first
Origin of life
Purpose
Replication first
Teleonomy

ASJC Scopus subject areas

Statistics and Probability
Modeling and Simulation
General Biochemistry, Genetics and Molecular Biology
Applied Mathematics