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Self-replicating amphiphilic β-sheet peptides
Simple peptides can do that too: Synthetic amphiphilic peptides 1, formed of electrophilic (E) and nucleophilic (N) precursors, are close analogues of the Glu-(Phe-Glu)n molecules. The peptides form soluble one-dimensional β-sheet aggregates in water (see picture), and serve to significantly accelerate chemical ligation and self-replication.
| Publication language | English |
| Pages | 6683-6686 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 48 |
| Issue number | 36 |
| Publication status | Published - 24.08.2009 |
Keywords
β sheet structures
Origins of life
Peptides
Self-replication
Systems chemistry
ASJC Scopus subject areas
Catalysis
General Chemistry
