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The road to non-enzymatic molecular networks

Zehavit Dadon, Nathaniel Wagner, Gonen Ashkenasy

This Minireview gives an overview of recent progress in the design and analysis of chemical systems that utilize template-directed autocatalytic and cross-catalytic processes as a means of wiring dynamically interacting molecules. Synthetic networks comprising two to nine replicating species are discussed. It is shown that for larger systems, more catalytic pathways must be manipulated to control the entire network topology and specific functionality of the individual species or subnetworks. Cellular biochemistry is an example of a natural functional molecular network; synthetic self-organized networks can provide additional models of complex systems.

Publication language English
Pages 6128-6136
Journal Angewandte Chemie - International Edition
Volume 47
Issue number 33
Publication status Published - 04.08.2008

Keywords

Minimal self-replication
Self-organized networks
Systems chemistry
Template-assisted catalysis

ASJC Scopus subject areas

Catalysis
General Chemistry
Access to Document
10.1002/anie.200702552
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Link to publication in Scopus