Menny Shalom

Senior Academic

Supporting Information A Versatile Photocatalytic System for H 2 Generation in Water Based on an Efficient

L Li, J Xu, J Lei, J Zhang, F McLarnon, Z Wei, Nan Li, F Pan, Kun Xu, Pengzuo Chen, Xiuling Li, Yun Tong, Hui Ding, Xiaojun Wu, Wangsheng Chu, Zheng Zhenmeng Peng, Changzheng Wu, Yi Xie, Menny Shalom, Debora Ressnig, Xiaofei Yang, Guylhaine Clavel, Tim Patrick Fellinger, Markus Antonietti, Seok-Hu Bae, Ji-Eun Kim, Hyacinthe Randriamahazaka, Song-Yi Moon, Jeong-Young Park, Il-Kwon Oh, Gao Feng Chen, Tian Yi Ma, Zhao Qing Liu, Nan Li, Yu Zhi Su, Kenneth Davey, Shi Zhang Qiao, Xunhui Xiong, Dong Ding, Dongchang Chen, Gordon Waller, Yunfei Bu, Zhixing Wang, Meilin Liu, Gengfeng Zheng, Zheng Zhenmeng Peng, Dingsi Jia, Abdullah M. Al-Enizi, Ahmed A. Elzatahry, Bo You, Nan Jiang, Xuan Liu, Yujie Sun, Dubois-type Nickel Catalyst, Manuela A Gross, Anna Reynal, James R Durrant, Erwin Reisner

Encephalopathy is an increasingly recognized complication of type 1 diabetes. The underlying mechanisms are not well understood, although insulin deficiency has been implicated. The spontaneously diabetic BB/Wor-rat develops neuro-behavioral deficits and neuronal cell death in hippocampus and frontal cortex, which can be prevented by insulinomimetic C-peptide. Here we examined whether contributing factors such as activation of innate immune mediators are responsive to C-peptide replacement. Seven-month diabetic BB/Wor-rats and those treated with full C-peptide replacement were compared to age-matched control rats. Hippocampi of diabetic rats showed upregulation of RAGE and NF-kappaB, the former being localized to proliferating astrocytes. These changes were associated with increased expression of TNF-alpha, IL-1beta, IL-2 and IL-6 in hippocampi of diabetic rats. Full C-peptide replacement, which did not induce hyperglycemia, resulted in significant prevention of upregulation of RAGE expression, activation of NF-kappaB and activation of pro-inflammatory factors. In conclusion, impaired insulin activity is associated with upregulation of RAGE and pro-inflammatory factors, and these are likely to contribute to previously described oxidative and apoptotic neuronal cell death. Replacement of insulinomimetic C-peptide significantly prevents this cascade of events.

Publication language	English
Pages	1-7
Publication status	Published - 2015

Keywords

H2production

High-performance

Nickel foam

Nickel hydroxide nanosheets

Supercapacitor

biomass upgrading

electrocatalysis

electrocatalysts

hydrogen evolution reaction

nanowires

nickel phosphide

oxygen evolution reaction

transition-metal electrocatalyst

water splitting

Sustainable Development Goals

SDG 7 - Affordable and Clean Energy