Maoz Shamir

Rhythmogenesis is the process that develops the capacity for rhythmic activity in a non-rhythmic system. Theoretical works suggested a wide array of possible mechanisms for rhythmogenesis ranging from the regulation of cellular properties to top–down control. Here we discuss theories of rhythmogenesis with an emphasis on spike timing-dependent plasticity. We argue that even though the specifics of different mechanisms vary greatly they all share certain key features. Namely, rhythmogenesis can be described as a flow on the phase diagram leading the system into a rhythmic region and stabilizing it on a specific manifold characterized by the desired rhythmic activity. Functionality is retained despite biological diversity by forcing the system into a specific manifold, but allowing fluctuations within that manifold.