Laboratory for Systems Chemistry
Prof. Gonen Ashkenasy Research Group
Artificial leucine rich repeats as new scaffolds for protein design
The leucine rich repeat (LRR) motif that participates in many biomolecular recognition events in cells was suggested as a general scaffold for producing artificial receptors. We describe here the design and first total chemical synthesis of small LRR proteins, and their structural analysis. When evaluating the tertiary structure as a function of different number of repeating units (1-3), we were able to find that the 3-repeats sequence, containing 90 amino acids, folds into the expected structure.
| Publication language | English |
| Pages | 2372-2375 |
| Volume | 21 |
| Issue number | 8 |
| Publication status | Published - 15.04.2011 |
Keywords
Leucine rich repeat proteins
Native chemical ligation
Peptides
Protein design
ASJC Scopus subject areas
Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry
