Laboratory for Systems Chemistry
Prof. Gonen Ashkenasy Research Group
Allosteric effects in coiled-coil proteins folding and lanthanide-ion binding
Peptide sequences modified with lanthanide-chelating groups at their N-termini, or at their lysine side chains, were synthesized, and new Ln(III) complexes were characterized. We show that partial folding of the conjugates to form trimer coiled coil structures induces coordination of lanthanides to the ligand, which in turn further stabilizes the 3D structure.
| Publication language | English |
| Pages | 9577-9579 |
| Volume | 48 |
| Issue number | 77 |
| Publication status | Published - 29.08.2012 |
ASJC Scopus subject areas
Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry
