Liron David Lab

The main interest of the lab is elucidating hierarchy of high order assembly formation in cancer, immunity and neurobiology. Hierarchy of higher order assemblies in immunity is a relatively fresh concept, which states that only upstream molecules can trigger the assembly of downstream molecules. This leads to a tightly regulated “all-or-none” response in the cell, which is a characteristic for immune pathways, and provide protection against malignant cells. The lab conducts interdisciplinary research combining structural biology, biochemistry and cell biology for studying mechanisms of soluble and membrane proteins involved in programmed cell death pathways and signaling pathways in immune cells.