פרופ' מיכאל דנילנקו

Michael Danilenko - SELECTED PUBLICATIONS (1999-2024)

1. Amir, H., Karas, M., Giat, J., Danilenko, M., Levy, R., Yermiahu, T., Levy, J., and Sharoni, Y. Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells, Nutr Cancer. 33: 105-112, 1999.
2. Danilenko, M., Wang, X., and Studzinski, G. P. Carnosic acid and promotion of monocytic differentiation of HL60-G cells initiated by other agents, J Natl Cancer Inst. 93: 1224-1233, 2001.
3. Steiner, M., Priel, I., Giat, J., Levy, J., Sharoni, Y., and Danilenko, M. Carnosic acid inhibits proliferation and augments differentiation of human leukemic cells induced by 1,25-dihydroxyvitamin D3 and retinoic acid, Nutr Cancer. 41: 135-144, 2001.
4. Danilenko, M., Wang, Q., Wang, X., Levy, J., Sharoni, Y. and Studzinski, G. P. Carnosic acid potentiates the antioxidant and prodifferentiation effects of 1?,25-dihydroxyvitamin D3 in leukemia cells, but does not promote elevation of basal levels of intracellular calcium, Cancer Res. 63: 1325-1332, 2003.
5. Gertsberg, I., Hellman, I., Fainshtein, M., Weil, S., Silberberg, S.D., Danilenko, M., Priel, Z. Intracellular Ca2+ regulates the phosphorylation and the dephosphorylation of ciliary proteins via the NO pathway. J Gen Physiol. 124: 527-540, 2004.
6. Danilenko, M. and Studzinski, G. P. Enhancement by other compounds of the anti-cancer activity of vitamin D3 and its analogs. Exp. Cell Res. 298: 339-358, 2004.
7. Ben-Dor, A., Steiner, M., Gheber, L., Danilenko, M., Doubi, N., Linnewiel, K., Zick, A., Sharoni, Y., Levy, J. Carotenoids activate the antioxidant response element transcription system, Mol Cancer Ther, 4: 177-186, 2005.
8. Wang, Q., Salman, H., Danilenko, M., Studzinski, G.P. Cooperation between antioxidants and 1,25-dihydroxyvitamin D3 in induction of leukemia HL60 cell differentiation through the JNK/AP-1/Egr-1 pathway. J Cell Physiol, 204: 964-974, 2005.
9. Sharabani, H., Izumchenko, E., Wang, Q., Kreinin, R., Steiner, M., Barvish, Z., Kafka, M., Sharoni, Y., Levy, J., Uskokovic, M., Studzinski, G. P., Danilenko, M. Cooperative Antitumor Effects of Vitamin D3 Derivatives and Rosemary Preparations in a Mouse Model of Myeloid Leukemia. Int J Cancer, 118:3012-3021, 2006.
10. Ozpolat, B., Akar, U., Steiner, M., Zorrilla-Calancha, I., Tirado-Gomez, M., Colburn, N., Danilenko M., Kornblau S., Lopez-Berestein, G. Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells. Mol Cancer Res, 5:95-108, 2007.
11. Zhang, J., Posner, G.H., Danilenko, M., Studzinski, G.P. Differentiation-inducing potency of the seco-steroid JK-1624F2-2 can be increased by combination with an antioxidant and a p38 MAPK inhibitor which upregulates the JNK pathway. J. Steroid Biochem & Mol Biol., 105:140-149, 2007.
12. Kim, S.H., Danilenko, M.. Kim, T.S. Differential enhancement of leukemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds. Brit. J. Pharmacol. 2008, 155:814-825.
13. Shabtay, A., Sharabani, H., Barvish, Z., Kafka, M., Amichay, D., Levy, Y., Sharoni, Y., Uskokovic, M.R., Studzinski, G.P., Danilenko, M. Synergistic Antileukemic Activity of Carnosic Acid-Rich Rosemary Extract and 19-nor Gemini Vitamin D Analog in a Mouse Model of Systemic Acute Myeloid Leukemia. Oncology, 75:203-214, 2008.
14. Zhang J., Harrison J.S., Uskokovic M., Danilenko M., Studzinski G.P. Silibinin can induce differentiation as well as enhance vitamin D3-induced differentiation of human AML cells ex vivo and regulates the levels of differentiation-related transcription factors. Hematol Oncol, 28: 124-132, 2010. PMID: 19866452.
15. Studzinski GP, Wang X, Danilenko M. DNA damage response: A barrier or a path to tumor progression? Cancer Biol Ther, 9:253-255, 2010. PMID: 20061811.
16. Pesakhov S, Khanin M, Studzinski GP, Danilenko M. Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid and silibinin on proliferation and apoptosis in acute myeloid leukemia cells. Nutr Cancer, 62:811-824, 2010. PMID: 20661831.
17. Thompson T., Danilenko M., Vassilev L., Studzinski G.P. Tumor suppressor p53 status does not determine the differentiation-associated G1 cell cycle arrest induced in leukemia cells by 1,25-dihydroxyvitamin D3 and antioxidants. Cancer Biol Ther, 10:344-350, 2010. PMID: 20543580.
18. Wang X, Gocek E, Novik V, Harrison JS, Danilenko M, Studzinski GP. Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D3. Cell Cycle, 9: 4542-4551, 2010. PMID: 21084834.
19. Bobilev I, Novik V, Levi I, Shpilberg O, Levy J, Sharoni Y, Studzinski GP, Danilenko M. The Nrf2 Transcription Factor is a Positive Regulator of Myeloid Differentiation of Acute Myeloid Leukemia Cells. Cancer Biol Ther, 11:317-329, 2011. PMID: 21099366.
20. Wassermann R, Novik V, Danilenko M. Cell type-specific effects of silibinin on vitamin D-induced differentiation of acute myeloid leukemia cells are associated with differential modulation of RXR? levels. Leuk Res Treatment. 2012:401784, 2012.
21. Wang, X., Pesakhov, S., Harrison, J.S., Danilenko, M., Studzinski, G.P. ERK5 pathway regulates transcription factors important for monocytic differentiation of human myeloid leukemia cells. J Cell Physiol 229: 856-867, 2014.
22. Wang, X., Pesakhov, S., Weng, A., Kafka, M., Gocek, E., Nguyen, M., Harrison, J.S., Danilenko, M., Studzinski, G.P. ERK5/MAPK pathway has a major role in 1?25-(OH)2D3-induced terminal differentiation of myeloid leukemia cells. J Steroid Biochem Mol Biol. 144PA:223-227, 2014.
23. Wang, X., Pesakhov, S., Harrison, J.S., Kafka, M., Danilenko, M., Studzinski, G.P. The MAPK ERK5, but not ERK1/2, inhibits the progression of monocytic phenotype to the functioning macrophage. Exp Cell Res 330:199-211, 2015.
24. Studzinski, G.P., Harrison, J.S., Wang, X., Sarkar, S., Kalia, V., Danilenko, M. Prospect: "Vitamin D Control of Hematopoietic Cell Differentiation and Leukemia." J Cell Biochem 116:1500-1512, 2015.
25. Linnewiel-Hermoni K, Khanin M, Danilenko M, Zango G, Amosi Y, Levy J, Sharoni Y. The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activity. Arch Biochem Biophys 572:28-35, 2015.
26. Nachliely M, Sharony E, Kutner A, Danilenko M. Novel analogs of 1,25-dihydroxyvitamin D2 combined with a plant polyphenol as highly efficient inducers of differentiation in human acute myeloid leukemia cells. J Steroid Biochem Mol Biol. 164:59-65, 2016.
27. Danilenko M, Studzinski GP. Keep Harm at Bay: Oxidative Phosphorylation Induces Nrf2-Driven Antioxidant Response via ERK5/MEF2/miR-23a Signaling to Keap-1. EBiomedicine, 3:4-5, 2016.
28. Pesakhov S, Nachliely M, Barvish Z, Aqaqe N, Schwartzman B, Voronov E, Sharoni Y, Studzinski GP, Fishman D, Danilenko M. Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid. Oncotarget, 7:31847-31861, 2016.
29. Zhamanbayeva GT, Aralbayeva AN, Murzakhmetova MK, Tuleukhanov ST, Danilenko M Cooperative antiproliferative and differentiation-enhancing activity of medicinal plant extracts in acute myeloid leukemia cells. Biomed Pharmacother, 82:80-89, 2016.
30. Nachliely M, Sharony E, Kutner A, Danilenko M. Prodifferentiation activity of novel vitamin D2 analogs PRI-1916 and PRI-1917 and their combinations with a plant polyphenol in acute myeloid leukemia cells. Int J Mol Sci 17:e1068, 2016.
31. Aralbaeva AN, Mamataeva AT, Zhaparkulova NI, Utegalieva RS, Khanin M, Danilenko M, Murzakhmetova MK. (2017) A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity. Biomed Pharmacother, 96:1283-1291.
32. Wang X, Nachliely M, Harrison JS, Danilenko M, Studzinski GP. (2019) Participation of vitamin D-upregulated protein 1 (TXNIP)-ASK1-JNK1 signalosome in the enhancement of AML cell death by a post-cytotoxic differentiation regimen. J Steroid Biochem Mol Biol, 87:166-173.
33. Nachliely M, Trachtenberg A, Khalfin B, Nalbandyan K, Cohen-Lahav M, Yasuda K, Sakaki T, Kutner A, Danilenko M. (2019) Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model. J Steroid Biochem Mol Biol, 188:8-16.
34. Ben Zichri S, Kolusheva S, Danilenko M, Ossikbayeva S, Stabbert WJ, Poggio J, Stein D, Orynbayeva Z, Jelinek R. (2019) Cardiolipin mediates curcumin interactions with mitochondrial membranes. BBA-Biomembranes, 1861:75-82.
35. Trachtenberg A, Muduli S, Sidoryk K, Cybulski M, Danilenko M. (2019) Synergistic Cytotoxicity of Methyl 4-Hydroxycinnamate and Carnosic Acid to Acute Myeloid Leukemia Cells via Calcium-Dependent Apoptosis Induction. Front Pharmacol, 10:507.
36. Wang X, Dawod A, Nachliely M, Harrison JS, Danilenko M, Studzinski GP. (2020) Differentiation agents increase the potential AraC therapy of AML by reactivating cell death pathways without enhancing ROS generation. J Cell Physiol, 235:573-586.
37. Zhumina AG, Li K, Konovalova AA, Li YA, Ishmuratova MY, Pogossyan GP, Danilenko M. (2020) Plasma 25-Hydroxyvitamin D Levels and VDR Gene Expression in Peripheral Blood Mononuclear Cells of Leukemia Patients and Healthy Subjects in Central Kazakhstan. Nutrients, 12:1229.
38. Wang X, Gupta P, Jramne Y, Danilenko M, Liu D, Studzinski GP. (2020) Carnosic acid increases sorafenib-induced inhibition of ERK1/2 and STAT3 signaling which contributes to reduced cell proliferation and survival of hepatocellular carcinoma cells. Oncotarget, 11:3129-3143.
39. Ossikbayeva S, Khanin M, Sharoni Y, Trachtenberg A, Tuleukhanov S, Sensenig R, Rom S, Danilenko M, Orynbayeva Z. (2021) Curcumin and carnosic acid cooperate to inhibit proliferation and alter mitochondrial function of metastatic prostate cancer cells. Antioxidants, 10:1591.
40. Trachtenberg A, Sidoryk K, Alreate S, Muduli S, Le? A, Cybulski M, Danilenko M. (2021) Structure-Activity Relationship of Hydroxycinnamic Acid Derivatives for Cooperating with Carnosic Acid and Calcitriol in Acute Myeloid Leukemia Cells. Biomedicines, 9:1517.
41. Muduli S, Golan-Goldhirsh A, Gopas J, Danilenko M. (2022) Cytotoxicity of Thioalkaloid-Enriched Nuphar lutea Extract and Purified 6,6'-Dihydroxythiobinupharidine in Acute Myeloid Leukemia Cells: The Role of Oxidative Stress and Intracellular Calcium. Pharmaceuticals (Basel), 15:410.
42. Bornshten R, Danilenko M, Rubin E. (2022) Projection of Expression Profiles to Transcription Factor Activity Space Provides Added Information. Genes, 13:1819.
43. Hallak M, Danilenko M, Win T, Bittner S, Granot Y, Shpilberg O, Levi I, Nathan I. (2023) Novel pyrrolidine-aminophenyl-1,4-naphthoquinones: Structure-related mechanisms of leukemia cell death. Mol Cell Biochem. 47:393-406.
44. Jramne-Saleem Y, Danilenko M. (2024) Roles of Glutathione and AP-1 in the Enhancement of Vitamin D-Induced Differentiation by Activators of the Nrf2 Signaling Pathway in Acute Myeloid Leukemia Cells. Int J Mol Sci, 25:2284.
45. Yestemirova GA, Yessimsiitova ZB, Danilenko M. (2024) Protective Effects of Dietary Vitamin D3, Turmeric Powder, and Their Combination against Gasoline Intoxication in Rats. Pharmaceuticals (Basel), 17:619.