מנהל מעבדה
הפקולטה למדעי הבריאות, ביה"ס לרפואה בין לאומית
ד"ר בוריס חלפין
יחידות
אזור צור קשר עם איש הסגל
פרסומים
1. Tsesin N, Khalfin B, Nathan I, Parola AH. Cardiolipin plays a role in KCN-induced Necrosis. Chem Phys Lipids 2014, 183:159-168. DOI: 10.1016/j.chemphyslip.2014.06.007.
2. Shapira MG, Khalfin B, Lewis EC, Parola AH, Nathan I. Regulation of autophagy by ?1-antitrypsin: 'a foe of a foe is a friend'. Mol Med 2014, 20(1):417?426. DOI: 10.2119/molmed.2014.00054.
3. Shadrin N, Shapira MG, Khalfin B, Uppalapati L, Parola AH, Nathan I. Serine protease inhibitors interact with IFN-? through up-regulation of FasR; a novel therapeutic strategy against cancer. Exp Cell Res 2015, 330(2):233-239. DOI: 10.1016/j.yexcr.2014.11.005.
4. Gorelick J, Yarmolinsky L, Budovsky A, Khalfin B, Klein J, Pinchasov Y, Bushuev MA, Rudchenko T, Ben-Shabat S. The impact of diet wheat source on the onset of Type 1 Diabetes mellitus ? lessons learnt from the Non Obese Diabetic (NOD) mouse model. Nutrients 2017, 9(5). DOI: 10.3390/nu9050482.
5. Gorelick J, Yarmolinsky L, Budovsky A, Khalfin B, Klein JD, Pinchasov Y, Bushuev MA, Rudchenko T, Ben-Shabat S. Reply: Diabetogenic Potential of Ancestral and Modern Wheat Landraces. Nutrients 2017, 9(9). DOI: 10.3390/nu9090922.
6. Meridor D, Cohen A, Khalfin B, Uppalapati L, Kasher R, Nathan I, Parola AH. The Protective Effect of Humanin Derivative AGA(C8R)-HNG17 Against Acetaminophen-Induced Liver Injury in Mice. Int J Pept Res Ther 2019, 25: 565?571 DOI: 10.1007/s10989-018-9700-2.
7. Yarmolinsky L, Budovsky A, Ben-Shabat S, Khalfin B, Gorelick J, Bishitz Y, Miloslavski R, Yarmolinsky L. Recent updates on the phytochemistry and pharmacological properties of Phlomis viscosa Poiret. Rejuvenation Res 2019, 22(4):282-288. DOI: 10.1089/rej.2018.2093
8. Nachliely M, Trachtenberg A, Khalfin B, Nalbandyan K, Cohen-Lahav M, Yasuda K, Sakaki T, Kutner A, Danilenko M. Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model. J Steroid Biochem Mol Biol 2019, 188:8-16. DOI: 10.1016/j.jsbmb.2018.11.017.
9. Yarmolinsky L, Budovsky A, Yarmolinsky L, Khalfin B, Glukhman V, Ben-Shabat S. Effect of Bioactive Phytochemicals from Phlomis viscosa Poiret on Wound Healing. Plants 2019, 8(12), 609; DOI: 10.3390/plants8120609.
10. Yagel Y, Sestito S, Motro Y, Shnaiderman-Torban A, Khalfin B, Sagi O, Navon-Venezia S, Steinman A, Moran-Gilad J. Genomic Characterization of Antimicrobial Resistance, Virulence, and Phylogeny of the Genus Ochrobactrum. Antibiotics 2020, 9(4), 177; DOI: 10.3390/antibiotics9040177.
11. Zaccai M, Yarmolinsky L, Khalfin B, Budovsky A, Gorelick J, Dahan A, Ben-Shabat S. Medicinal Properties of Lilium candidum L. and Its Phytochemicals. Plants 2020, 9(8):959. DOI: 10.3390/plants9080959.
12. Domanovich-Asor T, Motro Y, Khalfin B, Craddock HA, Peretz A, Moran-Gilad J. Genomic Analysis of Antimicrobial Resistance Genotype-to-Phenotype Agreement in Helicobacter pylori. Microorganisms 2020, 9(1):2. DOI: 10.3390/microorganisms9010002.
13. Domanovich-Asor T, Craddock HA, Motro Y, Khalfin B, Peretz A, Moran-Gilad J. Unraveling antimicrobial resistance in Helicobacter pylori: Global resistome meets global phylogeny. Helicobacter 2021, 26(2):e12782. DOI: 10.1111/hel.12782.
14. Khalfin B, Lichtenstein A, Albeck A, Nathan I. Targeting Necrosis: Elastase-like Protease Inhibitors Curtail Necrotic Cell Death Both In Vitro and in Three In Vivo Disease Models. J Med Chem 2021, 64(3):1510-1523. DOI: 10.1021/acs.jmedchem.0c01683.
15. Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021 17(1):1-382. DOI: 10.1080/15548627.2020.1797280.
16. Heno F, Azoulay Z, Khalfin B, Craddock HA, Silberstein E, Moran-Gilad J, Rapaport H. Comparing the Antimicrobial Effect of Silver Ion-Coated Silicone and Gentamicin-Irrigated Silicone Sheets from Breast Implant Material. Aesthetic Plast Surg 2021 45(6):2980-2989. DOI: 10.1007/s00266-021-02348-7.
17. Yarmolinsky Ludmila, Yarmolinsky Leonid, Khalfin B, Budovsky A, Ben-Shabat S. Influence of Conditions of GC- Flame Ionization Detector Analysis on Parameters of Peaks in Highly Concentrated Compounds. SBB 2021, 5(2). DOI: 10.31031/SBB.2021.05.000610.
18. Hochma E, Yarmolinsky L, Khalfin B, Nisnevitch M, Ben-Shabat S. Antimicrobial Effect of Phytochemicals from Edible Plants. Processes 2021, 9(11), 2089; DOI: 10.3390/pr9112089.
19. Kaniel O, Sherf-Dagan S, Szold A, Langer P, Khalfin B, Kessler Y, Raziel A, Sakran N, Motro Y, Goitein D, Moran-Gilad J. The effects of One Anastomosis Gastric Bypass surgery on the gastrointestinal tract. Nutrients 2022, 14(2), 304; DOI: 10.3390/nu14020304.
20. Zilberman B, Motro Y, Sagi O, Kornspan D, Ben-Shimol S, Gdalevich M, Yagel Y, Davidovitch N, Khalfin B, Rabinowitz P, Nesher L, Grotto I, Bardenstein S, Moran-Gilad J. Genomic Epidemiology of Clinical Brucella melitensis Isolates from Southern Israel. Microorganisms. 2022, 10(2):238. DOI: 10.3390/microorganisms10020238.
21. Craddock HA, Motro Y, Zilberman B, Khalfin B, Bardenstein S, Moran-Gilad J. Long-Read Sequencing and Hybrid Assembly for Genomic Analysis of Clinical Brucella melitensis Isolates. Microorganisms. 2022; 10(3):619. DOI: 10.3390/microorganisms10030619.
22. Cohen A, Poupko L, Craddock HA, Motro Y, Khalfin B, Zelinger A, Tirosh-Levy S, Blum SE, Steinman A, Moran-Gilad J. Fecal Microbiome Features Associated with Extended-Spectrum ?-Lactamase-Producing Enterobacterales Carriage in Dairy Heifers. Animals. 2022; 12(14):1738. DOI: 10.3390/ani12141738.
23. Sofer-Sali N, Roif-Kaminsky D, Motro Y, Khalfin B, Avramovich E, Galor I, Shlaifer A, Sommer A, Rutenberg R, Sachter Y, Yitzhak A, Grupel D, Moran-Gilad J. Prevalence and Characteristics of Carriage of Neisseria meningitidis Among Young Israeli Adults. Open Forum Infectious Diseases. 2022; 9(10) DOI: 10.1093/ofid/ofac482.
24. Yarmolinsky L, Budovsky A, Khalfin B, Yarmolinsky L, Ben-Shabat S. Medicinal Properties of Anchusa strigosa and Its Active Compounds. Molecules. 2022; 27(23):8239. DOI: 10.3390/molecules27238239.
25. Dahan S, Aibinder P, Khalfin B, Moran-Gilad J, Rapaport H. Hybrid Hydrogels of FKF-Peptide Assemblies and Gelatin for Sustained Antimicrobial Activity. ACS Biomater Sci Eng. 2023; 9(1):352-362. DOI: 10.1021/acsbiomaterials.2c01331.
26. Yarmolinsky L, Nakonechny F, Budovsky A, Zeigerman H, Khalfin B, Sharon E, Yarmolinsky L, Ben-Shabat S, Nisnevitch M. Antimicrobial and Antiviral Compounds of Phlomis viscosa Poiret. Biomedicines. 2023; 11(2):441. DOI: 10.3390/biomedicines11020441.
27. Lapid R, Motro Y, Craddock H, Khalfin B, King R, Bar-Gal GK, Moran-Gilad J. Fecal microbiota of the synanthropic golden jackal (Canis aureus). Anim Microbiome. 2023; 5(1):37. DOI: 10.1186/s42523-023-00259-3.
28. Gabarin A, Yarmolinsky L, Budovsky A, Khalfin B, Ben-Shabat S. Cannabis as a Source of Approved Drugs: A New Look at an Old Problem. Molecules. 2023 28(23):7686. DOI: 10.3390/molecules28237686.
29. Sharon N, Yarmolinsky L, Khalfin B, Fleisher-Berkovich S, Ben-Shabat S. Cannabinoids' Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases. Int J Mol Sci. 2024 25(12):6402. DOI: 10.3390/ijms25126402.
30. Yarmolinsky L, Nakonechny F, Haddis T, Khalfin B, Dahan A, Ben-Shabat S. Natural Antimicrobial Compounds as Promising Preservatives: A Look at an Old Problem from New Perspectives. Molecules. 2024; 29(24):5830. DOI: 10.3390/molecules29245830.
31. Dahan A, Yarmolinsky L, Budovsky A, Khalfin B, Ben-Shabat S. Phytochemicals of Callisia fragrans exhibit significant antimicrobial, pro-wound-healing, and anti-inflammatory properties. Phytomedicine Plus. 2025; 5(2):100780. DOI: 10.1016/j.phyplu.2025.100780.
32. Dahan A, Yarmolinsky L, Budovsky A, Khalfin B, Ben-Shabat S. Therapeutic Potential of Ficus benjamina: Phytochemical Identification and Investigation of Antimicrobial, Anticancer, Pro-Wound-Healing, and Anti-Inflammatory Properties. Molecules. 2025; 30(9):1961. DOI: 10.3390/molecules30091961.
33. Dahan A, Yarmolinsky L, Nakonechny F, Semenova O, Khalfin B, Ben-Shabat S. Etrog Citron (Citrus medica) as a Novel Source of Antimicrobial Agents: Overview of Its Bioactive Phytochemicals and Delivery Approaches. Pharmaceutics. 2025; 17(6):761. DOI: 10.3390/pharmaceutics17060761.
34. Dahan A, Yarmolinsky L, Nakonechny F, Semenova O, Khalfin B, Fleisher-Berkovich S, Ben-Shabat S. Etrog Citron (Citrus medica) as a Novel Source of Antiviral Agents: Overview of Its Bioactive Phytochemicals and Delivery Approaches. Pharmaceutics. 2025 17(9):1173. DOI: 10.3390/pharmaceutics17091173.
35. Dahan A, Oz M, Yarmolinsky L, Zahavi A, Goldenberg-Cohen N, Khalfin B, Ben-Shabat S, Lubin BCR. Multi-Target Neuroprotective Effects of Flavonoid-Rich Ficus benjamina L. Leaf Extracts: Mitochondrial Modulation, Antioxidant Defense, and Retinal Ganglion Cell Survival In-Vivo. Int. J. Mol. Sci. 2025 26(23):11746 DOI: 10.3390/ijms262311746.
2. Shapira MG, Khalfin B, Lewis EC, Parola AH, Nathan I. Regulation of autophagy by ?1-antitrypsin: 'a foe of a foe is a friend'. Mol Med 2014, 20(1):417?426. DOI: 10.2119/molmed.2014.00054.
3. Shadrin N, Shapira MG, Khalfin B, Uppalapati L, Parola AH, Nathan I. Serine protease inhibitors interact with IFN-? through up-regulation of FasR; a novel therapeutic strategy against cancer. Exp Cell Res 2015, 330(2):233-239. DOI: 10.1016/j.yexcr.2014.11.005.
4. Gorelick J, Yarmolinsky L, Budovsky A, Khalfin B, Klein J, Pinchasov Y, Bushuev MA, Rudchenko T, Ben-Shabat S. The impact of diet wheat source on the onset of Type 1 Diabetes mellitus ? lessons learnt from the Non Obese Diabetic (NOD) mouse model. Nutrients 2017, 9(5). DOI: 10.3390/nu9050482.
5. Gorelick J, Yarmolinsky L, Budovsky A, Khalfin B, Klein JD, Pinchasov Y, Bushuev MA, Rudchenko T, Ben-Shabat S. Reply: Diabetogenic Potential of Ancestral and Modern Wheat Landraces. Nutrients 2017, 9(9). DOI: 10.3390/nu9090922.
6. Meridor D, Cohen A, Khalfin B, Uppalapati L, Kasher R, Nathan I, Parola AH. The Protective Effect of Humanin Derivative AGA(C8R)-HNG17 Against Acetaminophen-Induced Liver Injury in Mice. Int J Pept Res Ther 2019, 25: 565?571 DOI: 10.1007/s10989-018-9700-2.
7. Yarmolinsky L, Budovsky A, Ben-Shabat S, Khalfin B, Gorelick J, Bishitz Y, Miloslavski R, Yarmolinsky L. Recent updates on the phytochemistry and pharmacological properties of Phlomis viscosa Poiret. Rejuvenation Res 2019, 22(4):282-288. DOI: 10.1089/rej.2018.2093
8. Nachliely M, Trachtenberg A, Khalfin B, Nalbandyan K, Cohen-Lahav M, Yasuda K, Sakaki T, Kutner A, Danilenko M. Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model. J Steroid Biochem Mol Biol 2019, 188:8-16. DOI: 10.1016/j.jsbmb.2018.11.017.
9. Yarmolinsky L, Budovsky A, Yarmolinsky L, Khalfin B, Glukhman V, Ben-Shabat S. Effect of Bioactive Phytochemicals from Phlomis viscosa Poiret on Wound Healing. Plants 2019, 8(12), 609; DOI: 10.3390/plants8120609.
10. Yagel Y, Sestito S, Motro Y, Shnaiderman-Torban A, Khalfin B, Sagi O, Navon-Venezia S, Steinman A, Moran-Gilad J. Genomic Characterization of Antimicrobial Resistance, Virulence, and Phylogeny of the Genus Ochrobactrum. Antibiotics 2020, 9(4), 177; DOI: 10.3390/antibiotics9040177.
11. Zaccai M, Yarmolinsky L, Khalfin B, Budovsky A, Gorelick J, Dahan A, Ben-Shabat S. Medicinal Properties of Lilium candidum L. and Its Phytochemicals. Plants 2020, 9(8):959. DOI: 10.3390/plants9080959.
12. Domanovich-Asor T, Motro Y, Khalfin B, Craddock HA, Peretz A, Moran-Gilad J. Genomic Analysis of Antimicrobial Resistance Genotype-to-Phenotype Agreement in Helicobacter pylori. Microorganisms 2020, 9(1):2. DOI: 10.3390/microorganisms9010002.
13. Domanovich-Asor T, Craddock HA, Motro Y, Khalfin B, Peretz A, Moran-Gilad J. Unraveling antimicrobial resistance in Helicobacter pylori: Global resistome meets global phylogeny. Helicobacter 2021, 26(2):e12782. DOI: 10.1111/hel.12782.
14. Khalfin B, Lichtenstein A, Albeck A, Nathan I. Targeting Necrosis: Elastase-like Protease Inhibitors Curtail Necrotic Cell Death Both In Vitro and in Three In Vivo Disease Models. J Med Chem 2021, 64(3):1510-1523. DOI: 10.1021/acs.jmedchem.0c01683.
15. Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021 17(1):1-382. DOI: 10.1080/15548627.2020.1797280.
16. Heno F, Azoulay Z, Khalfin B, Craddock HA, Silberstein E, Moran-Gilad J, Rapaport H. Comparing the Antimicrobial Effect of Silver Ion-Coated Silicone and Gentamicin-Irrigated Silicone Sheets from Breast Implant Material. Aesthetic Plast Surg 2021 45(6):2980-2989. DOI: 10.1007/s00266-021-02348-7.
17. Yarmolinsky Ludmila, Yarmolinsky Leonid, Khalfin B, Budovsky A, Ben-Shabat S. Influence of Conditions of GC- Flame Ionization Detector Analysis on Parameters of Peaks in Highly Concentrated Compounds. SBB 2021, 5(2). DOI: 10.31031/SBB.2021.05.000610.
18. Hochma E, Yarmolinsky L, Khalfin B, Nisnevitch M, Ben-Shabat S. Antimicrobial Effect of Phytochemicals from Edible Plants. Processes 2021, 9(11), 2089; DOI: 10.3390/pr9112089.
19. Kaniel O, Sherf-Dagan S, Szold A, Langer P, Khalfin B, Kessler Y, Raziel A, Sakran N, Motro Y, Goitein D, Moran-Gilad J. The effects of One Anastomosis Gastric Bypass surgery on the gastrointestinal tract. Nutrients 2022, 14(2), 304; DOI: 10.3390/nu14020304.
20. Zilberman B, Motro Y, Sagi O, Kornspan D, Ben-Shimol S, Gdalevich M, Yagel Y, Davidovitch N, Khalfin B, Rabinowitz P, Nesher L, Grotto I, Bardenstein S, Moran-Gilad J. Genomic Epidemiology of Clinical Brucella melitensis Isolates from Southern Israel. Microorganisms. 2022, 10(2):238. DOI: 10.3390/microorganisms10020238.
21. Craddock HA, Motro Y, Zilberman B, Khalfin B, Bardenstein S, Moran-Gilad J. Long-Read Sequencing and Hybrid Assembly for Genomic Analysis of Clinical Brucella melitensis Isolates. Microorganisms. 2022; 10(3):619. DOI: 10.3390/microorganisms10030619.
22. Cohen A, Poupko L, Craddock HA, Motro Y, Khalfin B, Zelinger A, Tirosh-Levy S, Blum SE, Steinman A, Moran-Gilad J. Fecal Microbiome Features Associated with Extended-Spectrum ?-Lactamase-Producing Enterobacterales Carriage in Dairy Heifers. Animals. 2022; 12(14):1738. DOI: 10.3390/ani12141738.
23. Sofer-Sali N, Roif-Kaminsky D, Motro Y, Khalfin B, Avramovich E, Galor I, Shlaifer A, Sommer A, Rutenberg R, Sachter Y, Yitzhak A, Grupel D, Moran-Gilad J. Prevalence and Characteristics of Carriage of Neisseria meningitidis Among Young Israeli Adults. Open Forum Infectious Diseases. 2022; 9(10) DOI: 10.1093/ofid/ofac482.
24. Yarmolinsky L, Budovsky A, Khalfin B, Yarmolinsky L, Ben-Shabat S. Medicinal Properties of Anchusa strigosa and Its Active Compounds. Molecules. 2022; 27(23):8239. DOI: 10.3390/molecules27238239.
25. Dahan S, Aibinder P, Khalfin B, Moran-Gilad J, Rapaport H. Hybrid Hydrogels of FKF-Peptide Assemblies and Gelatin for Sustained Antimicrobial Activity. ACS Biomater Sci Eng. 2023; 9(1):352-362. DOI: 10.1021/acsbiomaterials.2c01331.
26. Yarmolinsky L, Nakonechny F, Budovsky A, Zeigerman H, Khalfin B, Sharon E, Yarmolinsky L, Ben-Shabat S, Nisnevitch M. Antimicrobial and Antiviral Compounds of Phlomis viscosa Poiret. Biomedicines. 2023; 11(2):441. DOI: 10.3390/biomedicines11020441.
27. Lapid R, Motro Y, Craddock H, Khalfin B, King R, Bar-Gal GK, Moran-Gilad J. Fecal microbiota of the synanthropic golden jackal (Canis aureus). Anim Microbiome. 2023; 5(1):37. DOI: 10.1186/s42523-023-00259-3.
28. Gabarin A, Yarmolinsky L, Budovsky A, Khalfin B, Ben-Shabat S. Cannabis as a Source of Approved Drugs: A New Look at an Old Problem. Molecules. 2023 28(23):7686. DOI: 10.3390/molecules28237686.
29. Sharon N, Yarmolinsky L, Khalfin B, Fleisher-Berkovich S, Ben-Shabat S. Cannabinoids' Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases. Int J Mol Sci. 2024 25(12):6402. DOI: 10.3390/ijms25126402.
30. Yarmolinsky L, Nakonechny F, Haddis T, Khalfin B, Dahan A, Ben-Shabat S. Natural Antimicrobial Compounds as Promising Preservatives: A Look at an Old Problem from New Perspectives. Molecules. 2024; 29(24):5830. DOI: 10.3390/molecules29245830.
31. Dahan A, Yarmolinsky L, Budovsky A, Khalfin B, Ben-Shabat S. Phytochemicals of Callisia fragrans exhibit significant antimicrobial, pro-wound-healing, and anti-inflammatory properties. Phytomedicine Plus. 2025; 5(2):100780. DOI: 10.1016/j.phyplu.2025.100780.
32. Dahan A, Yarmolinsky L, Budovsky A, Khalfin B, Ben-Shabat S. Therapeutic Potential of Ficus benjamina: Phytochemical Identification and Investigation of Antimicrobial, Anticancer, Pro-Wound-Healing, and Anti-Inflammatory Properties. Molecules. 2025; 30(9):1961. DOI: 10.3390/molecules30091961.
33. Dahan A, Yarmolinsky L, Nakonechny F, Semenova O, Khalfin B, Ben-Shabat S. Etrog Citron (Citrus medica) as a Novel Source of Antimicrobial Agents: Overview of Its Bioactive Phytochemicals and Delivery Approaches. Pharmaceutics. 2025; 17(6):761. DOI: 10.3390/pharmaceutics17060761.
34. Dahan A, Yarmolinsky L, Nakonechny F, Semenova O, Khalfin B, Fleisher-Berkovich S, Ben-Shabat S. Etrog Citron (Citrus medica) as a Novel Source of Antiviral Agents: Overview of Its Bioactive Phytochemicals and Delivery Approaches. Pharmaceutics. 2025 17(9):1173. DOI: 10.3390/pharmaceutics17091173.
35. Dahan A, Oz M, Yarmolinsky L, Zahavi A, Goldenberg-Cohen N, Khalfin B, Ben-Shabat S, Lubin BCR. Multi-Target Neuroprotective Effects of Flavonoid-Rich Ficus benjamina L. Leaf Extracts: Mitochondrial Modulation, Antioxidant Defense, and Retinal Ganglion Cell Survival In-Vivo. Int. J. Mol. Sci. 2025 26(23):11746 DOI: 10.3390/ijms262311746.
