Amyloid proteins


We are interested in deciphering the fibrillation processes of amyloid peptides and their relationship with disease. In particular, we study the effect of membranes upon fibrillation processes of varied pathogenic and functional amyloidogenic proteins. We have also explored interactions of nanoparticles with amyloid proteins, and the contributions of protein/protein interactions to amyloid fibril formation and amyloid toxicity.

Recent Publications


  1. Revisiting thioflavin T (ThT) fluorescence as a marker of protein fibrillation – the prominent role of electrostatic interactions, Elad Arad, Hodaya Green, Raz Jelinek, Hanna Rapaport, Journal of Colloids & Interface Science, 2020, 573, 87-95.
  2. An Aβ42 double mutant inhibits Aβ42-induced plasma and mitochondrial membrane disruption in artificial membranes, isolated organs and intact cells, Ofek Oren, Shani Ben Zichri, Ran Taube, Raz Jelinek, Niv Papo, ACS Chemical Neuroscience, 2020, 11, 1027-1037.
  3. Imaging flow cytometry illuminates new dimensions of prion-protein membrane interactions, Reut Israeli, Sofiya Kolusheva, Uzi Hadad, Raz Jelinek, Biophysical Journal, 2020, 118, 1270-1278.
  4. Tryptophan-Glucosamine Conjugates Modulate Tau-Derived PHF6 aggregation at Low concentrations, Ashim Paul, Wen-Hao Li, Guru Viswanathan, Elad Arad, Satabdee Mohapatra, Gao Li, Raz Jelinek, Ehud Gazit, Yanmei Li, Daniel Segal, Chemical Communications, 2019, 55, 14621-14624.
  5. Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model, V. Guru KrishnaKumar, Dana Shwartz, Elad Arad, Edward Pichinuk, Hamutal Engel, Avi Raveh, Raz Jelinek, Ehud Gazit, Daniel Segal, Cellular and Molecular Life Sciences, 2019, in press.
  6. Unravelling the role of amino acid sequence order in the assembly and function of the amyloid-β core, Santu Bera, Elad Arad, Lee Schnaider, Shira Shaham-Niv, Valeria Castelletto, Yossef Peretz, Dor Zaguri, Raz Jelinek, Ehud Gazit, Ian Hamley ChemComm, 2019, 55, 8595-8599.
  7. Interactions between BIM protein and beta-amyloid may reveal a crucial missing link between Alzheimer's disease and neuronal cell death, Ravit Malishev, Sukhendu Nandi, Dariusz Śmiłowicz, Shamchal Bakavayev, Stanislav Engel, Nir Bujanover, Roi Gazit, Nils Metzler-Nolte, Raz Jelinek, ACS Chemical Neuroscience, 2019, 10, 3555-3564.
  8. Inhibitory Effect of Naphthoquinone-Tryptophan Hybrid towards Aggregation of PAP f39 Semen Amyloid, V. Guru KrishnaKumar, Satabdee Mohapatra, Ashim Paul, Elad Arad, Raz Jelinek, Ehud Gazit, Daniel Segal , Molecules, 2019, 23, 3279.
  9. Cardiolipin mediates curcumin interactions with mitochondrial membranes, Shani Ben-Zichri, Sofiya Kolushev, Michael Danilenko, Saniya Ossikbayeva, William J. Stabbert, Juan L. Poggio, David E. Stein, Zulfiya Orynbayeva, Raz Jelinek, BBA - Biomembranes, 2019, 1861, 75-82.
  10. Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots, Ravit Malishev, Elad Arad, Susanta Kumar Bhunia, Shira Shaham-Niv, Sofiya Kolusheva, Ehud Gazit, Raz Jelinek, Chemical Communications, 2018, 54, 7762-7765.
  11. Vesicle-based assays to study membrane interactions of amyloid peptides, Ravit Malishev, Raz Jelinek, Proteins in Misfolding Diseases, Springer Protocols – Methods in Molecular Biology, 2018, 1873, 39-52.
  12. Lysine-Derived Carbon Dots for Chiral Inhibition of Prion Peptide Fibril Assembly, Elad Arad, Susanta Kumar Bhunia, Juergen Jopp, Sofiya Kolusheva, Hanna Rapaport, Raz Jelinek, Advanced Therapeutics, 2018, in press.
  13. Nanoparticles modulate membrane interactions of human Islet amyloid polypeptide (hIAPP), Yossef Peretz, Ravit Malishev, Sofiya Kolusheva, Raz Jelinek, BBA-Biomembranes, 2018, 1860, 1810-1817.
  14. Reciprocal Interactions between Membrane Bilayers and Staphylo-coccus aureus PSMα3 Cross-α Amyloid-like Fibrils Provide Mechanistic Insight into Species-specific Cytotoxicity, Ravit Malishev, Einav Tayeb-Fligelman, Shimrit David, Meytal Landau, Raz Jelinek,Journal of Molecular Biology, 2018, 430, 1431-1441.
  15. Bacterial model membranes reshape fibrillation of a Bacillus subtilis functional amyloid protein, Ravit Malishev, Razan Abbasi, Raz Jelinek, Liraz Chai*,Biochemistry, 2018, 57, 5230−5238.
  16. Membrane Determinants Affect Fibrillation Processes of β-sheet Charged Peptides, Elad Arad, Ravit Malishev, Hanna Rapaport, Raz Jelinek, Biomacromolecules, 2018, 19, 307-314.
  17. Bacoside-A, an Indian traditional medicine substance, inhibits beta amyloid cytotoxicity, fibrillation, and membrane interactions, Ravit Malishev, Shira Shaham-Niv, Sofiya Kolusheva, Sukhendu Nandi, Ehud Gazit, Raz Jelinek, ACS Chemical Neuroscience, 2017, 8(4), 884-891.
  18. Bacoside-A, an anti-amyloid natural substance, inhibits membrane disruption by the amyloidogenic determinant of prion protein through accelerating fibril formation, R. Malishev, S. Nandi, S. Kolusheva, S. Shaham-Niv, Ehud Gazit, Raz Jelinek, BBA-Biomembranes, 2016, 1858, 2208-2214.
  19. Toxicity inhibitors protect lipid membranes from disruption by Aβ42, Ravit Malishev, Sukhendu Nandi, Sofiya Kolusheva, Yael Levi-Kalisman, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan, Raz Jelinek, ACS Chemical Neurosciences, 2015, 6(11), 1860-1869.
  20. Lipid Bilayers Significantly Modulate Cross-Fibrillation of Two Distinct Amyloidogenic Peptides, Noga Gal, Ahiud Morag, Sofiya Kolusheva, Roland Winter, Meytal Landau, Raz Jelinek, Journal of the American Chemical Society, 2013, 135, 13582-13589.
  21. Aggregation modulators interfere with membrane interactions of β2-microglobulin fibrils, Tania Sheynis, Anat Friediger, Wei-Feng Xue, Andrew L. Hellewell, Kevin W. Tipping, Eric W. Hewitt, Sheena E. Radford, Raz Jelinek, Biophysical Journal, 2013, 105, 745-755.
  22. Heparin inhibits membrane interactions and lipid-induced fibrillation of a prion amyloidogenic determinant, Ehud Bazar, Tania Sheynis, Jerzy Dorosz, Raz Jelinek, ChemBioChem, 2011, 12, 761-767.