Bacterial sensing

We discovered that the new lipid/PDA assemblies can be applied for bacterial and bacterial biofilm detection. In particular, we have discovered that PDA can be embedded within different transparent host matrixes, such as agar-gels and silica sol-gel. Importantly, the PDA domains in such assemblies can be utilized for color and fluorescence sensing of bacterialpresence and biofilm formation. The new sensing techniques could become a versatile and useful tool for detecting bacterial contaminations in varied environments, biofilm formation, and applied for high throughput screening of bacterial resistance to antibiotic compounds and biofilm inhibitors.

Relevant Publications
  1. Biofilm formation on chromatic sol-gel/polydiacetylene films, Margarita Ritenberg, Sofiya Kolusheva, Hadas Ganin, Michael Meijler, Raz Jelinek, ChemPlusChem, 2012, 77, 752-757.

    [Full Paper]

  2. Polydiacetylene-supported silica biosensing films formed at the air/water interface”, Y. Demihovsky, S. Kolusheva, M. Geyzer, R. Jelinek, Journal of Colloids and Interface Science, 2011, 364, 428-434.

    [Full Paper]

  3. Colorimetric/fluorescent bacterial sensing by agarose-embedded lipid/polydiacetylene films”, Dror Meir, Liron Silbert, Roman Volinsky, Sofiya Kolusheva, Irit Weizer, Raz Jelinek, Journal of Applied Microbiology, 2008, 104, 787-795.

    [Full Paper]

  4. Colorimetric fingerprinting of bacteria by glass-supported lipid/polydiacetylene films”, Yogesh Scindia, Liron Silbert, Roman Volinsky, Sofiya Kolusheva, Raz Jelinek, Langmuir, 2007, 23, 4682-4687. (Selected to be a special News Feature in Materials Today, May 2007).

    [Full Paper]

  5. Rapid chromatic detection of bacteria using a new biomimetic polymer sensor, Liron Silbert, Izek Ben Shlush, Elena Israel, Angel Porgador, Sofiya Kolusheva, Raz Jelinek, Appl. Environ. Microbiology, 2006, 72, 7339-7344. (Featured in the Journal Highlights section of Microbe, January 2007).

    [Full Paper]