Professor Abraham H. Parola

Carol and Barry Kaye Chair in Applied Science

Department of Chemistry,

The Faculty of Natural Sciences

Ben-Gurion University,

P.O. Box 653, Beer Sheva, Israel, 84105.

Tel: 972 8 647 2454 mobile: 972 52 8 795945

Fax: 972 8 6472943



Research Interests:

1.   Membrane dynamic changes associated with viral, chemical and electromagnetic cell transformation and malignancy.

2.   Adenosine deaminase (ADA) and adenosine deaminase complexing protein (ADCP = CD26 = DPPIV) in cell transformation: biophysical manifestation of membrane dynamics; reconstitution in liposomes; effect of lipid composition, cholesterol and phase transition on ADA activity; spectroscopic deciphering of passive modulation,   site accessibility and hydrophobic mismatching models.

3.   Protein-drug interaction: fibroblast growth factor-2 (bFGF) and the antiangiogenic drug Suradista.

4.   Membrane dynamics, cellular signaling and ciliary motion.

5.   Bacterial cell cycle and the transertion model: DnaA and membrane domains.

6.   Protein-protein interactions: effect of cold inactivation on the quaternary structure of tryptophanase; point mutations, x-ray crystallography structure determination; quorum sensing and biofilm formation; searching for a new generation of antibiotics

7.   Free radicals and bioelectromagnetics; do high voltage wire lines cause cancer?

8.   Programmed cell death: apoptosis, necrosis and autophagy.

9.   Protective effect of humanin and Its derivatives against necrotic cell death

10.              Diagnostics:

a.     Fluorescence immunoassays

b.     Non-invasive determination of fetal lung maturity

c.      Development and design of archetype equipment for the detection of drugs in body fluids without reagents utilizing time resolved laser spectroscopy; 3D and synchronous fluorescence spectra

d.     resolved laser spectroscopy; 3D and synchronous fluorescence spectra

e.      Homeland security: detection of poisons in water resources

f.       Development of a fluorescence assay for Interferon

Spectrofluorometry is the major method used in the above: single photon correlation and multifrequency phase modulation for lifetime, anisotropy decay and energy-transfer studies; fluorescent affinity labels; fluorescent probes.