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F5 to view the latest version Last updated Dec 23, 2022 |
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Camp Evolution VIII Sede-Boqer
Campus, December 18 – 22, 2022 Featuring Dmitri Petrov Michelle and Kevin Douglas Professor
of Biology and the Director of the Program
for Conservation Genomics Stanford University on Populations Genomics and Systems Biology of Rapid
Evolution |
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Organizers: Ariel Novoplansky
and Gili Greenbaum
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Previous workshops: Camp Evolution I: Sympatric Speciation and Evolution of
Sex Camp Evolution II: Evolutionary and Ecological Genomics Camp Evolution III:
Human Evolutionary Genetics Camp Evolution IV:
Unresolved Problems in Evolutionary Biology Camp Evolution V: Plant
Evolutionary Biology after Darwin Camp Evolution VI:
Evolution on Fitness Landscapes Camp Evolution VII:
Control theory in evolution and development |
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Lecture recordings: |
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The workshop aims at bringing together full-fledged scholars and
graduate students interested in anything evolutionary…
Optional- students can earn 2 academic credits (BGU course # 001-2-3335)
pending the submission of a written assignment.
Adaptation by natural selection is the central process in evolution and
is at the core of some of the greatest problems facing humanity. From cancer to
viral and bacterial pathogenicity, to evolution of drug and pesticide
resistance, to agriculture and survival of biological diversity in the face of
rapid global change, many of our most daunting challenges are related to rapid
evolutionary adaptation.
Adaptation was generally thought of as idiosyncratic and difficult to
study - adaptive mutations are rare, happened a long time ago, and have been obscured
by subsequent changes. Yet, to build a rich and predictive theory of
adaptation, one must first obtain rich empirical data. We must identify
individual adaptive mutations, understand their effects first on phenotypes and
then on fitness across environments. We must do it at scale where we can infer
probability distributions rather than rely on individual examples. Ultimately,
because rapid evolution is occurring on timescales of ecology, one must also
understand how rapid evolution interacts with ecological dynamics.
In this course we will explore theoretical and empirical underpinning of
our understanding of rapid adaptation from standing genetic variation –
including the investigation of the forces that maintain functional genetic
variation in populations – and from de novo mutations. We will explore the
dynamics of non-mutation-limited adaptation regimes that lead to clonal
interference and soft selective sweeps and empirical means to study adaptation
in this regime. We will investigate the properties of large adaptive jumps,
events that are often derided as hopeful monsters and yet which are now being
shown to be commonplace. Finally we will investigate how the ability to
generate a large and representative set of adaptive mutations is allowing us
now to start building full genotype-phenotype-fitness maps of adaptation.
Getting there, local amenities etc.
· Reaching Beer-Sheva from Tel-Aviv is best done
by train
· From Jerusalem you should better take an Egged bus
· To Midreshet Ben-Gurion (mind you- not Kibbutz
Sede-Boker), take Metropolin buses 60 or 64
from Beer-Sheva's Central bus station.
· The auditorium, The Ben-Gurion Research Institute for
the Study of Israel and Zionism, Bldg 23, Sede-Boqer
Campus
· Proper meals can be ordered at the Sede Boqer field school but there are a few
local eateries, a grocery store and a pub.
· All participants are welcome to join a dinner
party on Wed, Dec 21, 2022.
· Please bring with you layered clothing (days can
be nice and cozy but nights can be chilly), hiking shoes and a swimsuit (no
promises but it might become useful in our hikes).
First day (Sunday, Dec 18, 2022):
· Participants staying at the local
hostel/guesthouse are kindly requested to check in at the Sede-Boqer Field School Office (#13 on map of Midreshet
Ben-Gurion)
· Get together: 13:00
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Orientation: 13:15
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First lecture: 13:30
@ The auditorium, The Ben-Gurion Research Institute for the Study of Israel and Zionism, Bldg 23, Sede-Boqer
Campus
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Sun, Dec 18 |
Mon, Dec 19 |
Tue, Dec 20 |
Wed, Dec 21 |
Thu, Dec 22 |
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08:30 – 10:15 |
Arrival and check-in |
How common is adaptation? How large are the adaptive
jumps? Molecular population genetics and genomics perspective |
Experimental
microbial evolution and direct observation and quantification of rapid
evolution
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Theory
of adaptation. Fisher’s geometric model and adaptive walks |
Building
genotype-phenotype-fitness maps of adaptation |
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10:15 – 10:30 |
Coffee break |
Coffee break |
Coffee break |
Coffee break |
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10:30 – 12:15 |
Get together: 13:00 Orientation: 13:15 |
Mutation-limited
and non-mutation-limited regimes of adaptation. Soft sweeps. Theory and data |
Experimental
evolution in seminatural mesocosms |
Empirical
quantification of fitness landscapes. Steepness, ruggedness, and diminishing
returns |
Pareto
optimality and tradeoffs |
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12:15 – 13:15 |
Lunch break |
Lunch break |
Lunch break |
Lunch break |
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13:30 – 18:00 |
Foundations of population
genetics. The key problematics Visit to the
David Ben-Gurion Archives |
Excursion: Hike: Nachal Karkash, down the Zin |
Excursion: Hike: down the Ramon Crater |
Excursion: Hike: Snapir Katan @ Chatira Crater |
Goodbyes |
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19:00 – 20:15 |
Supper break |
Supper break |
Supper break |
Conference dinner |
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20:30 – 21:30 |
The dynamics of adaptation under very prolonged resource exhaustion |
Admixture between Neandertals, Denisovans and Ancient Modern Humans |
Extremely rapid evolution in the wild - are gene drives a good idea? |
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