Shaul Mordechai, PhD
Professor of
Physics
Head, Biomedical Spectroscopy
Department of Physics,
Beer
Tel: 972-8-6461-749
Fax: 972-8-6467-903
Email: shaulm@bgumail.bgu.ac.il
Education:
MSc. 1965-1967 Racah Inst. of Physics,
PhD. 1967-1971 Racah Inst. of Physics,
Research
Interest:
1992-1993 |
Visiting scientist,
Department of Physics, The University |
1990-present |
Full Professor, Department of Physics, |
1987-1989
|
Visiting Scientist,
Department of Physics, The |
1984-1985 |
Research
Faculty, Department of Physics, University of |
1982-1989 |
Associate Professor, Department of Physics, BGU. |
1983-1984 |
Visiting Research Investigator, Department of Physics, |
1975-1982 |
Senior Lecturer, Department of Physics, BGU. |
1976-1978 |
Research
Investigator, Department of Physics, |
1972-1975 |
Lecturer, Department of Physics, |
Referee in International
Journals
1. Nature Medicine
2. The Lancet Oncology
3. Physical Review Letters
4. Biophysical Journal
5. J. Biomedical Optics
6. Applied Optics
7. European Biophysics Journal
8. Vibrational Spectroscopy
9. Archives of Biochemistry and Biophysics
10.
Physical Chemistry Chemical Physics
11.
Int. J. Rad. Biology
12.
Optical Engineering
13.
Australian J. of Chemistry
Refereed Publications (past five
years only)
1. S. Walfisch,
H. Mnitentag, S. Mordechai and A. Gersten,
Keywords: Diamond shaped fiberoptic system; Delivery systems; Biological
tissues.
Keywords:
3. A. Salman, S. Argov, R.
Jagannathan, J. Goldstein,
Keywords: FT-IR; microspectrometry;
4. R. Jagannathan, A. Salman, N. Grossman,
Z. Hammody, B. Cohen and S.
Keywords: Cancer; Mouse
fibroblasts; Ras oncogene; Fourier transform IR microscopy; Spectral fitting.
5. R. Jagannathan, A. Salman,
S. Argov, J. Goldstein, I. Sinelnikov, S.
Keywords:
6. N. Grossman, E. Ilovitz, O. Chaims, A.
Salman, R. Jagannathan, S. Mark, B.
Keywords: Endogenous
fluorescence; Optical diagnosis; Cancer; Fibroblasts; H-ras.
7. R. Jagannathan, A. Salman, Z. Hammody,
B. Cohen, J. Gopas, N. Grossman
Keywords: FTIR microscopy;
Fibroblasts; Cancer; Oncogenes; H-ras.
8.
M. Huleihel, A. Salman, V. Erukhimovitch, R. Jagannathan, Z. Hammody and S.
Mordechai, “Novel Optical Method
for Study of Viral Carcinogenesis in Vitro”, J. Biochem
Biophys Methods, Vol. 50, (2-3), pp.111-121, 2002.
Keywords:
FTIR microscopy; Cancer; Diagnosis;
Malignant cells; Retroviruses; IR spectroscopy; NIH/3T3 cells
9. R. Jagannathan, S. Argov, A.
Salman, M. Yuzhelevski, I. Sinelnikov, J.
Keywords:
10. Oleg Kleiner, Jagannathan
Ramesh, Mahmoud Huleihel, Beny Cohen, Keren Kantarovich, Chen Levi, Borris
Polyak, Robert Marks, Jacov Mordehai, Zahavi Cohen and Shaul Mordechai, “Application of FTIR spectroscopy and
Fluorescence Microscopy for the Analysis of Gallstones", BioMed
Central Gastroenterology, 2(1): 3, 2002.
Keywords: Gallstones, FTIR-spectroscopy; Fluorescence microscopy;
Risk factors.
11. S. Argov, Jagannathan Ramesh, A. Salman, Jed
Goldstein, I. Sinelnikov, Hugo Guterman, and S. Mordechai, “Diagnostic Potential of FTIR Microspectroscopy and Advanced
Keywords:
12. Jagannathan Ramesh,
Kapelushnik J, Mordehai J, Moser A, Huleihel M, Erukhimovitch V, Levi C, Mordechai
S, “Novel Methodology for the follow-up
of acute lymphoblastic leukemia in children”, J. Bioch Biophy Methods, Vol. 51, pp. 251-261
Keywords: Acute lymphoblastic leukemia; Drugs; Follow-up;
Lymphocytes; FTIR microspectroscopy.
Keywords: Fibroblast; MuSV; FTIR microspectroscopy; Cluster analysis.
14. Jagannathan
Ramesh, Mahmoud Huleihel, Jacov
Mordehai, Asher Moser,
Keywords: ALL, Chemotherapy; Blast; FTIR-microspectroscopy;
Biological markers; Cluster analysis.
15. S. Mordechai, S. Argov, R. K. Sahu, S.
Walfisch, H. Gutrman, I. Sinelnikov, A. Salman, J. Goldestein, "FTIR-microspectroscopy: A new effective
quantitative method for diagnosis of cancer", Acta Histochem. Vol. 105(4), pp. 354 2003.
Keywords:
16. Jacov Mordehai
, Jagannathan Ramesh, Mahmoud Huleihel, Zahavi Cohen, Oleg Kleiner,
Marina Talyshinsky, Vitaly Erukhimovitch, Aviv Cahana, Ahmad Salman, Ranjit Kumar Sahu, Hugo
Guterman and Shaul Mordechai, “STUDIES ON ACUTE HUMAN INFECTIONS
USING FTIR MICROSPECTROSCOPY AND CLUSTER ANALYSIS
Keywords: FTIR; Blood; Infection; Diagnosis; Cluster analysis.
17. S. Mark, R.K. Sahu, K. Kantarovich,
A. Podshyvalov, H. Guterman, J. Goldstein, R. Jagannathan, S. Argov and S.
Mordechai, "Fourier Transform
Infrared Microspectroscopy as a quantitative diagnostic tool for assignment of
premalignancy grading in cervical neoplasia" J. Biomed. Optics, Vol. 9(3), pp. 557-567,
2004.
Keywords: Cervical intraepithelial neoplasia,
Staging, Fourier transformed infrared microspectroscopy, Histology review,
Probabilistic neural networks.
Keywords:
19. S. Mordechai, R.K. Sahu, Z. Hammody, S. Mark, K.
Kantarovich, A. Podshyvalov, J. Goldestein and S. Argov, "POSSIBLE Common
biomarkers from ftir-microspectroscopy of cervical cancer and melanoma",
J. of Microscopy, Volume 215 (1), Pp 86-91, 2004.
Keywords: Cervical cancer, melanoma, FTIR-MSP, RN/DNA ratio,
Diagnosis.
20. R.K. Sahu, S. Argov, E. Bernshtain,
A. Salman, S. Walfisch, J. Goldestein and S. Mordechai
"Detection of abnormal proliferation in
histologically “
Keywords: Fourier Transform Infrared Microspectroscopy,
21. Y. Mizrachi, N. Porat, S. Lifshitz, S. Novick, A. Levi, E. Ling, O.
Liron, S. Mordechai, R.K. Sahu and R. Dagan, "VIRULENCE OF
STREPTOCOCCUS PNEUMONIAE MAY BE DETERMINED INDEPENDENTLY OF CAPSULAR
POLYSACCHARIDE", FEMS Microbiology Letters, Vol. 233, pp.
147-152, 2004.
Keywords: Streptococcus peneumonia, Capsular polysaccaride, Virulence
factors, Microbial pathogenesis
22.
Shmuel Argov ,Ranjit K. Sahu, Evgenia Bernshtain, Ahmad Salman, Guy
Shohat, Udi Zelig, and Shaul Mordechai, “Inflamatory
Bowel Diseases as an Intermediate Stage Between Normal and Cancer:A
FTIR-Microspectroscopy Approach”, Biopolymers Vol. 75(5),
pp 384-92, Dec 2004.
Keywords: Inflamatory Bowel Disease (IBD),
23.
R. K. Sahu, , S. Argov, , A. Salman, M. Huleihel, , N. Grossman, Z. Hammody, , J. Kapelushnik, and S. Mordechai “Characteristic absorbance of nucleic acids in the Mid-IR region as
possible common biomarkers for diagnosis of malignancy”, Technology
in Cancer Research & Treatment, Volume 3( 6), Pp 629-638, 2004.
Keywords: Nucleic
acids, FTIR, Malignancy, Biomarkers
24. R. K. Sahu, S. Argov, A. Salman, U.Zelig, M. Huleihel, N. Grossman, J. Gopas,
J. Kapelushnik and S. Mordechai " Can
FTIR-Spectroscopy at Higher
Wavenumbers (mid IR) Shed Light on Biomarkers for Carcinogenesis in
Tissues?" . J. Biomed. Optics, Vol. 10, No. 5, 2005.
Keywords:
FTIR-Spectroscopy, Biomarkers, carcigenesis
Keywords: Cervical
Cancer, FTIR-MSP, Probabilistic Neural Netwaorks
26. R.K. Sahu and
27.
Ranjit Kumar
Sahu, Udi Zelig, Mahmoud Huleihel,
Nir Brosh, Marina Talyshinsky, Miriam Ben-Harosh, Shaul
Mordechai and Jossi Kapelushnik. ” Continuous monitoring of WBC (biochemistry) in an adult
leukemia patient using advanced
FTIR-spectroscopy” Leuk. Res. Vol 30 (6), Pp. 687-93, 2006.
28. R. K. Sahu, S. Mordechai, S. Pesakhov, R. Dagan, and N. Porat. “Use of FTIR Spectroscopy to Distinguish between Capsular Types and Capsular Quantities in Streptococcus pneumoniae” Biopolymers, 83(4):434-42, 2006.
29. Evgeny Bogomolny, Mahmoud Huleihel,Yelena Suproun, Ranjit Sahu and Shaul Mordechai. “Early spectral changes of cellular malignant transformation using Fourier transform infrared microspectroscopy” Journal of Biomedical Optics (JBO), 12 ( 2), 2007.
30. Z. Hammody, M. Huleihal, A. Salma, S. Argov, R. Moreh, A. Katzer, S. Mordechai, “Potential of 'Flat' Fiber Evanescent Wave Spectroscopy to Discriminate Between Normal and Malignant Cells in vitro,“ J. of Microscopy, In Press, 2007.
Chapter in Books
1. "TECHNIQUES IN INFREARED
MICROSPECTROSCOPY & ADVANCED COMPUTATIONAL METHODS FOR
2. “NEW APPROACHES TO CERVICAL
CANCER DIAGNOSIS USING FTIR-SPECTROSCOPY”, By R.K Sahu,
Proceedings in International Conferences / Meeting (past five
years only)
1. S. Mordechai, A. Salman, S. Argov, O. Haims, B. Cohen,
V. Erukhimovitch,
Keywords: Cancer diagnosis; FTIR
microscopy; Intestinal cancer; Epithelial cells; Band fitting.
2. S. Mordechai, S. Argov, A. Salman, B.
Cohen, R. Jagannathan, V.
Keywords: Cancer diagnosis;
FTIR-microspectroscopy; Intestinal cancer; Epithelial cells; Band fitting.
Keywords: Cancer, Mouse fibroblast
cell culture; Ras oncogene; micro-FTIR; Band fitting.
Keywords: Light-Iinduced
Fluorescence; Cancer diagnosis; Fibroblasts; Ras .
5. S.
Mordechai, J. Mordechai , Jagannathan Ramesh, C. Levi, A. Moser, V.
Erukhimovitch, M. Huleihel, and J. Kapelushnik, “Application of FTIR Microscopy for the Follow up of Childhood
Leukemia Chemotherapy”, in Subsurface and Surface Sensing
Technologies and Applications III, Cam Nguyen Editor, Proceedings of SPIE Vol.
4491, pp. 243-250, 2001.
Keywords:
Acute lymphoblastic leukemia, Childhood,
Chemotherapy, FTIR microspectroscopy.
6. S.
Mordechai, S. Mark, A. Podshyvalov, K. Kantarovich, E. Bernshtain, A. Salman, V. Erukhimovitch, H.
Guterman, J. Goldstein, S. Argov, R. Jagannathan, "Comparative studies on cervical and colonic
malignancies using FTIR-microspectroscopy" Proceedings
of SPIE, Vol. 5047,
Pp. 367-377, 2003.
Keywords:
FT-IR microspectroscopy,
7. S.
Mordechai, S. Argov,
R.K. Sahu, A. Podshyvalov and S. Mark "SIGNATURE
OF MALIGNANCY IN FOURIER TRANSFORMED INFRARED MICROSPECTROSCOPY IN CERVICAL CANCER", Joint
International Laser Conference, Laser in Medical Science Vol. 18, Supplement 1,
Edinburgh, Scotland, 2003.
Keywords: Cervical cancer, Histology
review, Histology Review, FTIR-microspectroscopy, Probabilistic neural
networks.
8. S. Mordechai, R.K. Sahu , Z. Hammody, S.
Mark, K. Kantarovich, S. Argov, A. Podshyvalov, and J. Goldstein "Common biomarkers from FTIR-microspectrscopy
of cervical cancer and melanoma", Book of Abstracts, 1st
International Meeting on Applied Physics,
Keywords: Cervical cancer; Melanoma;
FTIR-MSP; Diagnosis; PNN.
9.
R.K. Sahu , S. Argov, A. Salman, U. Zelig, J. Kapelushnik and S. Mordechai "CHARACTERISTIC aBSORBANCE OF nUCLEIC aCIDS AS
POSSIBLE pARAMETER FOR dISTINCTION OF CANCER AND NORMAL TISSUES USING
fTIR-MICROSPECTROSCOPY", Raman and IR Spectroscopy in Biology
and Medicine RISBM 2004, p. 19 Jena, Germany.
Keywords: FTIR-Microscopy, Nucleic
Acids, Cancer, Tissue, Cell Lines.
10. Z. Hammody, R.K. Sahu , S. Argov and
S. Mordechai, "CHARACTERIZATION
OF MALIGNANT melanoma using VIBRATIONAL SPECTROSCOPY ",
Raman and IR Spectroscopy in Biology and Medicine RISBM 2004, pp. 55,
Keywords: Malignant Melanoma; Nevus,
FTIR-Microscopy; RNA; DNA.
11. S. Mordechai, R.K. Sahu, M. Huleihel, U. Zelig, B. Nir,
M. Talyshinsky, M. Ben-Harosh and J. Kapelushnik, "MONITORING CHANGES
IN BLOOD COMPONENTS DURING TREATMENT OF LEUKEMIA USING ADVANCED
FTIR-MICROSPECTROSCOPY", Shedding New Light on Disease: Optical
Diagnosis for the New Millenium, 2004,
Keywords: Leukemia, FTIR,
Chemotherapy, Blood
12. S. Argov, R. Sahu, Z. Hammody, S.
Ahmad, E. Cagnano and S. Mordechai, "NEW DIRECTION IN DIAGNOSIS OF
MALIGNANCY USING VIBRATIONAL SPECTROSCOPY", The 12th International
Congress of Histochemistry and Cytochemistry, July
Keywords: FTIR-Microscopy,
13. R. K. Sahu, N. Porat, S. Pesakhov
and S. Mordechai, "VARIATIONS IN FTIR SPECTRA BETWEEN OPAQUE AND
TRANSPARENT PHENOTYPIC VARIANTS OF
STREPTOCOCCUS PNEUMONIAE",
FT-IR Spectroscopy in Microbiological and Medical Diagnostic, October 2004,
Berlin, Germany
14.
Z. Hammody, R.K. Sahu, S. Mordechai, E. Cagnano and S. Argov, "IDENTIFICATION
OF DIAGNOSTIC WAVENUMBERS FOR DETECTION OF MALIGNANT MELANOMA USING FEWS SYSTEM",
83 International Bunsen Discussion meeting, October 2004, Dresden,
Germany
15.
R.K.Sahu, J.Kapelushnik, M.Huleihel,
N.Grossman, S.Ahmad, U.Zelig, S. Argov and S.Mordechai," COMMON
FEATURES OF CARCINOGENIC CELLS AND TISSUES USING FTIR-MICROSPECTROSCOPY:
IMPLICATIONS OF ABSORBANCE IN THE HIGHER WAVENUMBERS IN CANCER DIAGNOSIS",83
International Bunsen Discussion meeting, October 2004, Dresden, Germany.
16.
S. Mordechai, S. Argov,
U. Zelig, and R. K. Sahu,
" PROGRESSION OF NORMAL CERVICAL TISSUES TO CANCER THROUGH
INTRAEPITHELIAL NEOPLASIA USING INFRARED MICROSPECTROSCOPY
17. R. K. Sahu, J. Kapelushnik, H. Mahmoud,
U. Zelig, B. Nir, M.Talshinsky,
M. Ben-Harosh and S. Mordechai, " CHANGES IN PLASMA
DURING TREATMENT OF LEUKEMIA USING
ADVANCED FTIR-MICROSPECTROSCOPY ", Israel Physical Society, 50th
Annual Meeting , December 2004, Technion Haifa, Israel.
18. Shlomo Walfisch, Ranjit Kumar Sahu, Shmuel Argov and Shaul Mordechai
19. R.K. Sahu, S. Argov, S. Walfisch
and S. Mordechai, "
20. Shaul Mordechai “Assessment of Abnormal Proliferation (Premalignancy) in Colon Resection Margins Using FTIR-microspectroscopy”, Bi-National Israel-Italian Optronics Workshop, Ben-Gurion University, Beer-Sheeva, Israel, 2005. Invited talk.
21. S. Mordechai, S. Argov, S. Walfisch, H. Guterman, R. Moreh, A. Salman and R.K. Sahu “ FTIR Spectroscopy in Diagnosis of Colon Cancer: Promises and Challenges”, Shedding Light on Disease: Optical Diagnosis for the New Millennium, Spec 2006, Heidelberg, Germany, 2006. Invited talk.
22. Z. Hammody, R.K. Sahu,
23. R.K. Sahu, S. Mordechai and E. Manor “ Detection
of DNA Signals in FTIR Spectra of a Dividing Lymphoblastic Cell Line”,
Shedding Light on Disease: Optical Diagnosis for the New Millennium, Spec 2006,
in Cellular Malignant Transformation Using
Vibrational Spectroscopy”, The XXVIIIth European Congress on Molecular Spectroscopy (EUCMOS XXVIII) ,
26. Udi
Zelig, Ilana Nathan, Joseph Kapelushnik and Shaul Mordechai “Diagnosis and
monitoring leukemia patients' response to chemotherapy using FTIR spectroscopy”,
4th International
Conference On Advanced Vibrational
Spectroscopy,
27. R.K. Sahu, S. Argov , S. Walfisch ,
and S. Mordechai “Predictability
of colonic cancer recurrence using the
crypt model and FTIR-microscopy”, 3th International Congress on Gastrointestinal Oncology,
1. Israeli Patent (Patent Registration Number
: 146521) titled “NOVEL OPTICAL METHOD FOR DIAGNOSIS AND GRADING OF
PREMALIGNANT AND MALIGNANT HUMAN COLONIC TISSUES”.
2. International Patent Application (PCT/IL02/00912) titled: "Novel Optical Method for Diagnosis and Staging of Premalignant and Malignant Human Colonic Tissues".