Colorimetric sensors


Our laboratory has been working for several years on development of colorimetric and fluorescent sensors based upon polydiacetylene (PDA) – a unique conjugated polymer. We have demonstrated applications of varied PDA-based sensor configurations, including vesicles, solid-supported films, PDA/sol-gel constructs, and PDA-labeled live cells, and investigated their use in chemical- and biological sensing applications.


Recent Publications

  1. ”Colorimetric Polydiacetylene-Aerogel Detector for Volatile Organic Compounds (VOCs), Susmita Dolai, Susanta Kumar Bhunia, Stella Beglaryan, Sofiya Kolusheva, Leila Zeiri, Raz Jelinek, ACS Advanced Materials and Interfaces, 2017, in press.
  2. ”Polydiacetylene sensor interaction with food sanitizers and surfactants, Yueyuan Zhang, Julie Northcutt, Tim Hanks, Ian Miller, Bill Pennington, Raz Jelinek, Inyee Han, Paul Dawson, Food Chemistry, 2017, 221, 515-520.
  3. Colorimetric analysis of painting materials using polymer-supported polydiacetylene films, Alexander Trachtenberg, Orit Malka, Kaviya Parambath Kootery, Stella Beglaryan, Danilo Malferrari, Paola Galletti, Silvia Prati, Rocco Mazzeo, Emilio Tagliavini, Raz Jelinek, New J. Chem., 2016, 40, 9054-59.
  4. Light-Induced Conductivity in a Solution-Processed Film of Polydiacetylene and Perylene Diimide, H. Jiang, G. Hershtig, S. Richter, Raz Jelinek, Journal of Physical Chemistry Letters, 2016, 7, 1628-1631.
  5. Pomegranate Juice Polyphenols Induce Macrophage Death via Apoptosis as oppose to Necrosis Induced by Free Radical Generation: a Central Role for Oxidative Stress, O. Rom, N. Volkova, S. Nandi, Raz Jelinek, M. Aviram, The Journal of Cardiovascular Pharmacology, 2016, in press.
  6. Hierarchical assembly of polydiacetylene microtubes mediated by divalent metal ions, H. Jiang, Raz Jelinek, ChemPlusChem, 2016, 81, 119-124.
  7. Chromatic polymer assays for the analysis of lipid and lipoprotein peroxidation, Raz Jelinek, Sofiya Kolusheva, Ella Mann, Michael Aviram, Lipid Technology, 2015, 27(4), 86-89.
  8. Mixed diacetylene/octadecyl melamine nanowires formed at the air/water interface exhibit unique structural and colorimetric properties, Jiang Hao, Raz Jelinek, Langmuir, 2015, 31, 5843-5850.
  9. Colorimetric polymer assay for the diagnosis of plasma lipids atherogenic quality in hypercholesterolemic patients, Ella Mann, Sofiya Kolusheva, Rami Yosef, Angel Porgador, Michael Aviram, Raz Jelinek, Molecular Diagnosis and Therapy, 2015, 19, 35-43.
  10. Poly(methyl methacrylate)-supported polydiacetylene films: unique chromatic transitions and molecular sensing, Kaviya Parambath Kootery, Hao Jiang, Sofiya Kolusheva, T. P. Vinod, Margarita Ritenberg, Leila Zeiri, Roman Volinsky, Danilo Malferrari, Paola Galletti, Emilio Tagliavini, Raz Jelinek, ACS Applied Materials and Interfaces, 2014, 6, 8613-8620.
  11. Polydiacetylenes – Recent Molecular Advances and Applications, Raz Jelinek, Margarita Ritenberg, RSC Advances, 2013, 3(44), 21192-21201.
  12. Array-based disease diagnostics using lipid/polydiacetylene vesicles encapsulated in a sol-gel matrix, S. Kolusheva, R. Yossef, A. Kugel, M. Katz, R. Volinsky, M. Welt, U. Hadad, V. Drory, M. Kliger, E. Rubin, A. Porgador, Raz Jelinek, Analytical Chemistry, 2012, 84, 5925–5931.
  13. Biofilm formation on chromatic sol-gel/polydiacetylene films, Margarita Ritenberg, Sofiya Kolusheva, Hadas Ganin, Michael Meijler, Raz Jelinek, ChemPlusChem, 2012, 77, 752-757.
  14. Polydiacetylene-supported silica biosensing films formed at the air/water interface , Y. Demihovsky, S. Kolusheva, M. Ritenberg, Raz Jelinek, Journal of Colloids and Interface Science, 2011, 364, 428-434.


Lipid/PDA biomimetic membranes
Lipid/PDA vesicles

PDA-labeled live cells

Lipid/PDA monolayers and films

Chromatic giant vesicles

PDA-based bacterial sensing