Amyloid proteins


We are interested in deciphering the fibrillation processes of amyloid peptides and their relationship with disease. In particular, we study the effect of membranes upon fibrillation processes of varied pathogenic and functional amyloidogenic proteins. We have also explored interactions of nanoparticles with amyloid proteins, and the contributions of protein/protein interactions to amyloid fibril formation and amyloid toxicity.

Recent Publications


  1. Lysine-Derived Carbon Dots for Chiral Inhibition of Prion Peptide Fibril Assembly, Elad Arad, Susanta Kumar Bhunia, Juergen Jopp, Sofiya Kolusheva, Hanna Rapaport, Raz Jelinek, Advanced Therapeutics, 2018, in press.
  2. Nanoparticles modulate membrane interactions of human Islet amyloid polypeptide (hIAPP), Yossef Peretz, Ravit Malishev, Sofiya Kolusheva, Raz Jelinek, BBA-Biomembranes, 2018, in press.
  3. Reciprocal Interactions between Membrane Bilayers and Staphylo-coccus aureus PSMα3 Cross-α Amyloid-like Fibrils Provide Mechanistic Insight into Species-specific Cytotoxicity, Ravit Malishev, Einav Tayeb-Fligelman, Shimrit David, Meytal Landau, Raz Jelinek,Journal of Molecular Biology, 2018, in press.
  4. Bacterial model membranes reshape fibrillation of a Bacillus subtilis functional amyloid protein, Ravit Malishev, Razan Abbasi, Raz Jelinek, Liraz Chai*,Biochemistry, 2018, in press.
  5. Membrane Determinants Affect Fibrillation Processes of β-sheet Charged Peptides, Elad Arad, Ravit Malishev, Hanna Rapaport, Raz Jelinek, Biomacromolecules, 2018, 19, 307-314.
  6. Bacoside-A, an Indian traditional medicine substance, inhibits beta amyloid cytotoxicity, fibrillation, and membrane interactions, Ravit Malishev, Shira Shaham-Niv, Sofiya Kolusheva, Sukhendu Nandi, Ehud Gazit, Raz Jelinek, ACS Chemical Neuroscience, 2017, 8(4), 884-891.
  7. Bacoside-A, an anti-amyloid natural substance, inhibits membrane disruption by the amyloidogenic determinant of prion protein through accelerating fibril formation, R. Malishev, S. Nandi, S. Kolusheva, S. Shaham-Niv, Ehud Gazit, Raz Jelinek, BBA-Biomembranes, 2016, 1858, 2208-2214.
  8. Toxicity inhibitors protect lipid membranes from disruption by Aβ42, Ravit Malishev, Sukhendu Nandi, Sofiya Kolusheva, Yael Levi-Kalisman, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan, Raz Jelinek, ACS Chemical Neurosciences, 2015, 6(11), 1860-1869.
  9. Lipid Bilayers Significantly Modulate Cross-Fibrillation of Two Distinct Amyloidogenic Peptides, Noga Gal, Ahiud Morag, Sofiya Kolusheva, Roland Winter, Meytal Landau, Raz Jelinek, Journal of the American Chemical Society, 2013, 135, 13582-13589.
  10. Aggregation modulators interfere with membrane interactions of β2-microglobulin fibrils, Tania Sheynis, Anat Friediger, Wei-Feng Xue, Andrew L. Hellewell, Kevin W. Tipping, Eric W. Hewitt, Sheena E. Radford, Raz Jelinek, Biophysical Journal, 2013, 105, 745-755.
  11. Heparin inhibits membrane interactions and lipid-induced fibrillation of a prion amyloidogenic determinant, Ehud Bazar, Tania Sheynis, Jerzy Dorosz, Raz Jelinek, ChemBioChem, 2011, 12, 761-767.