Raz Jelinek - Recent Publications

    1. Biofilm formation on chromatic sol-gel/polydiacetylene films , Margarita Geyzer, Sofiya Kolusheva, Hadas Ganin, Michael Meijler, R. Jelinek, , ChemPlusChem, 2012, in press.
    2. Highly compacted DNA nanoparticles with low MW PEG coatings: in vitro, ex vivo and in vivo evaluation, Nicholas J. Boylan, Jung Soo Suk, Samuel K. Lai, R. Jelinek, , Michael P. Boyle, Mark J. Cooper, and Justin Hanes Journal of Controlled Release, 2012, 157, 72-29.
    3. Polydiacetylene-supported silica biosensing films formed at the air/water interface , Y. Demihovsky, S. Kolusheva, M. Geyzer, R. Jelinek, , Journal of Colloids and Interface Science, 2011, 364, 428-434.
    4. N-methyl-substituted fluorescent DAG-indololactone isomers exhibit dramatic differences in membrane interactions and biological activity , Noga Gal, Sofiya Kolusheva, Noemi Kedei, Andrea Telek, Nancy E. Lewin, Langston Lim, Poonam Mannan, Susan H. Garfield, Säid El Kazzouli, Dina M. Sigano, Victor E. Marquez, Peter M. Blumberg, R. Jelinek, , ChemBioChem, 2011, 12, 2331-2340.
    5. Self-Assembled Transparent Conductive Electrodes from Au Nanoparticles in Surfactant Monolayer Templates , A. Morag, L. Philosof-Mazor, R. Volinsky, E. Mentovich, S. Richter, R. Jelinek, , Advanced Materials, 2011, 23, 4327-4331.
    6. A Paradigm for Solvent and Temperature Induced Conformational Changes”, Dina Shpasser,Yael S. Balazs, Moshe Kapon, Tania Sheynis, R. Jelinek, , Moris Eisen, Chemistry- A European Journal, 2011, 17, 8285-8289.
    7. Some phorbol esters may partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells , Noemi Kedei, Emanuel Lubart, Nancy E. Lewin, Andrea Telek, Langston Lim, Poonam Mannam, Sofiya Kolusheva, Susan H. Garfield, Gary E. Keck, R. Jelinek, , Peter Blumberg, ChemBioChem, 2011, 12, 1242-1251 .
    8. Heparin inhibits membrane interactions and lipid-induced fibrillation of a prion amyloidogenic determinant, Ehud Bazar, Tania Sheynis, Jerzy Dorosz, R. Jelinek, ChemBioChem, 2011, 12, 761-767.
    9. “Gold Nanoparticle Self-Assembly in Two-Component Lipid Langmuir Monolayers”, Alina Mogilevsky, R. Jelinek, Langmuir, 2011, 27, 1260-1268 [Full Paper]
    10. “Fibrillation of human calcitonin inhibits lipid interactions of membrane-active molecules”, Tania Sheynis, R. Jelinek, Journal of Physical Chemistry B, 2010, 110, 15530-15535 [Full Paper]
    11. “Membrane interactions of novicidin, a novel antimicrobial peptide: phosphatidylglycerol promotes bilayer insertion”, Jerzy Dorosz, Sofiya Kolusheva, Yana Gofman, Daniel Otzen, Nir Ben Tal, Niels Chr. Nielsen, R. Jelinek, Journal of Physical Chemistry B, 2010, 110, 11053-11060 [Full Paper]
    12. “Divergent heparin-induced fibrillation pathways of a prion amyloidogenic determinant”, E. Bazar, R. Jelinek, ChemBioChem, 2010, 11, 1997-2002 [Full Paper]
    13. Membrane-surface anchoring of charged diacylglycerol-lactones correlates with biological activities, Or Raifman, Sofiya Kolusheva, Said El Kazzouli, Dina M. Sigano, Noemi Kedei, Nancy E. Lewin, Ruben Lopez-Nicolas, Ana Ortiz-Espin, Juan C. Gomez-Fernandez, Peter M. Blumberg, Victor E. Marquez, Senena Corbalan, R. Jelinek, ChemBioChem, 2010, 11, 2003-2009
    14. “Specific mutations alter fibrillation kinetics, fiber morphologies, and membrane interactions of pentapeptides derived from human calcitonin”, Amit Shteinfeld, Tania Sheynis, R. Jelinek, Biochemistry, 2010, 49, 5299-5307. [Full Paper]
    15. “Biophysical techniques for studying membrane interactions of amyloid peptides”, Tania Sheynis, R. Jelinek, Current Protein and Peptide Science, 2010, 11, 318-328. [Full Paper]
    16. “Gold nanoparticle self-assembly in saturated phospholipid monolayers”, A. Mogilevsky, R. Volinsky, Y. Dayagi, N. Markovich, R. Jelinek, Langmuir, 2010, 26, 7893-7898. [Full Paper]
    17. “The Effect of Backbone Cyclization on PK/PD Properties of Bioactive Peptide-Peptoid Hybrids: The Melanocortin Agonist Paradigm”, O. Ovadia, Y. Linde, C. Haskell-Luevano, M. L. Dirain, T. Sheynis, R. Jelinek C. Gilon, A. Hoffman, Bioorganic and Medicinal Chemistry, 2010, 18, 580-589. [Full Paper]
    18. “Membrane anchoring of diacylglycerol-lactones substituted with rigid hydrophobic acyl domains correlates with biological activities”, O. Raifman, S. Kolusheva, M. J. Comin, N. Kedei, N. E. Lewin, P. M. Blumberg, V. E. Marquez, R. Jelinek, The FEBS Journal, 2010, 277, 233-243. [Full Paper]
    19. “Lipoprotein Interactions with Chromatic Membranes as a Novel Marker for Oxidative Stress – Related Diseases”, N. Hanin-Avraham, B. Fuhrman, A. Mech-Dorosz, S. Kolusheva, A. Porgador, M. Aviram, R. Jelinek, BBA-Biomembranes, 2009, 1788, 2436-2443. [Full Paper]
    20. Lipid-Modulated Pharmacophore Nanofibers at the Air/Water Interface, L. Philosof-Mazor, R. Volinsky, J. Jopp, H. Rapaport, P. M. Blumberg, V. E. Marquez, R. Jelinek, ChemPhysChem, 2009, 10, 2615-2619.
    21. “Phospholipid Monolayer-Induced Fibrillation of a Prion Amyloidogenic Determinant”, J. Dorosz, R. Volinsky, E. Bazar, S. Kolusheva, R. Jelinek, Langmuir, 2009, 25, 12501–12506. [Full Paper]
    22. Laser-Modulated Ordering of Au Nanoparticles at the Air/Water Interface, R. Volinsky, R. Jelinek, Angewandte Chemie International Edition in English, 2009, 48, 4540-4542. Designated a Very Important Paper (VIP).
    23. Conformationally Constrained Analogues of Diacylglycerol (DAG). 31. Modulation of the Biological Properties of Diacylgycerol Lactones (DAG-lactones) Containing Rigid-Rod Acyl Groups Separated From the Core Lactone by Spacer Units of Different Lengths”, M. J. Comin, G. Czifra, N. Kedei, N. E. Lewin, S. Kolushev, J. F. Velasquez, R. Kobylarz, R. Jelinek, P. M. Blumberg, V. E. Marquez, Journal of Medicinal Chemistry, 2009, 52, 3274-3283.
    24. “Biomimetic Approaches for Studying Membrane Processes”, R. Jelinek, L. Silbert, Molecular BioSystems, 2009, 5, 811-818. [Full Paper]
    25. “Gold Nanostructures in Diacetylene Monolayer Templates”, N. Markovich, R. Volinsky, R. Jelinek, Journal of the American Chemical Society, 2009, 131, 2430-2431. [Full Paper]
    26. “Screening Membrane Interactions of Pesticides by Cells Decorated with Chromatic Polymer Nanopatches”, A. Mech-Dorosz, Z. Orynbayeva, K. Irgebayev, S. Kolusheva, R. Jelinek, Chemical Research in Toxicology, 2009, 22, 90-96. [Full Paper]
    27. "Colorimetric Polymer Films for Predicting Lipid Interactions and Percutaneous Adsorption of Pharmaceutical Formulations", Ben-Shlush, R. Volinsky, M. Katz, Y. Scindia, R. Itzhak, H. TsahorOhayon, I. Yosha, R. Jelinek, Pharmaceutical Research, 2008, 25, 2815-2821. [Full Paper]
    28. “Mechanisms of alpha-Defensin Bactericidal Action: Comparative Membrane Disruption by Cryptdin-4 and Its Disulfide-Null Analogue”, C. Hadjicharalambous, T. Sheynis, R. Jelinek, A. J. Ouellette, E. Gizeli, Biochemistry, 2008, 47, 12626-12634. [Full Paper]
    29. "Self-assembly and lipid interactions of diacylglycerol-lactone derivatives studied at the air/water interface”, Liron Philosof-Mazor, Roman Volinsky, Maria J. Comin, Nancy E. Lewin, Peter M. Blumberg, Victor E. Marquez, R. Jelinek, Langmuir, 2008, in press. [Full Paper]
    30. “Lipid/Polydiacetylene Films for Colorimetric Protein Surface-Charge Analysis”, S. Friedman, S. Kolusheva, R. Volinsky, L. Zeiri, T. Schrader, and R. Jelinek, Anal. Chem., 2008, 80, 7804–7811. [Full Paper]
    31. “Membrane interactions and lipid binding of casein oligomers and early aggregates”, Miri Sokolovski, Tania Sheynis, Sofiya Kolusheva, R. Jelinek, Biochimica et Biophysica Acta Biomembranes, 2008, in press.
    32. "Colorimetric polymer films for predicting lipid interactions and percutaneous adsorption of pharmaceutical formulations", Izek Ben-Shlush, Roman Volinsky, Marina Katz, Yogesh Scindia, Racheli Itzhak, Hila Tsahor Ohayon, Ido Yosha, R. Jelinek, Pharmaceutical Research. 2008, in press.
    33. "Pardaxin, a fish toxin peptide interaction with a biomimetic phospholipid/polydiacetylene membrane assay", Sofiya Kolusheva, Shimon Lecht, Yael Derazon, R. Jelinek,Philip Lazarovici, Peptides 2008, in press.
    34. Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues, Eric Biron, Jayanta Chatterjee, Oded Ovadia, Daniel Langenegger, Joseph Brueggen, Daniel Hoyer, Herbert A. Schmid, R. Jelinek, Chaim Gilon, Amnon Hoffman, Horst Kessler, Angew. Chemie, Intl. Ed. Eng. 2008, 47, 2595 –2599.
    35. “Membrane processes and biophysical characterization of living cells decorated with chromatic polydiacetylene vesicles", Natalie Groysman, Zulfiya Orynbayeva, Marina Katz, Sofiya Kolusheva, Marina Khanin, Michael Danilenko, R. Jelinek, Biochimica et Biophysica Acta Biomembranes, 2008, 1778, 1335-1343. [Full Paper]
    36. “The Effect of Structural and Conformation Modifications, Including Backbone Cyclization, of Hydrophilic Hexapeptides on their Intestinal Permeability and Enzymatic Stability”, Shmuel Hess, Oded Ovadia, Deborah E. Shalev, Hanoch Senderovich, Bashir A.Qadri, Tamar Yehezkel, Yoseph Salitra, Tania Sheynis, R. Jelinek, Chaim Gilon, Amnon Hoffman, Journal of Medicinal Chemistry, 2007, in press. [Full Paper]
    37. “Giant chromatic lipid/polydiacetylene vesicles for detection and visualization of membrane interactions”, Alexander Pevzner, Sofiya Kolusheva, Zulfiya Orynbayeva, R. Jelinek, Advanced Functional Materials, 2008, 18, 242-247. [Full Paper]
    38. “Colorimetric/fluorescent bacterial sensing by agarose-embedded lipid/polydiacetylene films”, Dror Meir, Liron Silbert, Roman Volinsky, Sofiya Kolusheva, Irit Weizer, R. Jelinek, Journal of Applied Microbiology, 2008, 104, 787-795. [Full Paper]
    39. “The use of solvent relaxation technique to investigate interfacial properties and protein binding of simple and mixed phosphatidylcholine/surfactant bilayer membranes.” K. Rieber, J. Sýkora, A. Olzynska, R. Jelinek, G. Cevc, M. Hof, Biochimica and Biophysica Acta Biomembranes, 2007, 1768, 1050-1058. [Full Paper]
    40. “Colorimetric fingerprinting of bacteria by glass-supported lipid/polydiacetylene films”, Yogesh Scindia, Liron Silbert, Roman Volinsky, Sofiya Kolusheva, R. Jelinek, Langmuir, 2007, 23, 4682-4687. (Selected to be a special News Feature in Materials Today, May 2007). [Full Paper]
    41. "Biomolecular sensing with colourimetric vesicles”, R. Jelinek, Sofiya Kolusheva, Topics in Current Chemistry, 2007, vol. 277, (Schrader T., Ed.) [Full Paper]
    42. "Vaccinia virus interactions with the cell membrane studied by new chromatic vesicle and cell sensor assays" Z.Orynbayeva, S.Kolusheva, N.Groysman, N.Gavrielov, L.Lobel, R. Jelinek, J. Virology, 2007, 81(3), 1140-1147. (Featured in the JVI Spotlight, as a special meritorious article). [Full Paper]
    43. "Glass-supported lipid/polydiacetylene films for colour sensing of membrane-active compounds" Roman Volinsky, Sofiya Kolusheva, Tania Sheynis, Mark Kliger, R. Jelinek, Biosensors & Bioelectronics, 2007, 22, 3247-3251. [Full Paper]
    44. "Matrix Metalloproteinase-7 Activation of Mouse Paneth Cell Pro-a-Defensins: Ser43,Ile44 Proteolysis Enables Membrane Disruptive Activity" Hiroki Tanabe, Jason E. Cummings, Steve P. Crampton, Tanya Sheynis, R. Jelinek, T. Kyle Vanderlick, Melanie Cocco, Andre J. Ouellette, J. Biol. Chem., 2006, 281, 28932-28942.
    45. "Color fingerprinting of proteins by calixarenes embedded in lipid/polydiacetylene vesicles" Sofiya Kolusheva, Reza Zadmard, Thomas Schrader, R. Jelinek, J. Am. Chem. Soc.,128, 13592-13598. [Full Paper]
    46. "Rapid chromatic detection of bacteria using a new biomimetic polymer sensor" Liron Silbert, Izek Ben Shlush, Elena Israel, Angel Porgador, Sofiya Kolusheva, R. Jelinek, Appl. Environ. Microbiology, 2006, 72, 7339-7344. (Featured in the Journal Highlights section of Microbe, January 2007). [Full Paper]
    47. "Investigations of antimicrobial peptides in planar film systems" R. Volinsky, S. Kolusheva, A. Berman, R. Jelinek, Biophysica Biochimica Acta – Biomembranes,2006, 1758, 1393-1407. [Full Paper]
    48. "Rapid colorimetric screening of drug interaction and penetration through lipid barriers" Marina Katz, Izek Ben Shlush, Sofiya Kolusheva, R. Jelinek, Pharmaceutical Research, 2006, 23(3), 580-588. [Full Paper]
    49. "Imaging membrane processes in erythrocyte ghosts by surface fusion of a chromatic polymer" Elena Shtelman, Sofiya Kolusheva, R. Jelinek, Analytical Biochemistry, 2006, 348, 151-153. [Full Paper]
    50. "A Microwave-assisted Synthesis of Nanosized MgO and its Use as a Bacteriocide" S. Makhluf, R. Dror, Y. Nitzan , Y. Abramovich, R. Jelinek, A. Gedanken, Advanced Functional Materials, 2005, 15, 1708-1715. [Full Paper]
    51. “Membrane interactions and metal-ion effects on bilayer permeation of the lipophilic ion modulator DP-109”, Sofiya Kolusheva, Jonathan Friedman, Itzchak Angel, R. Jelinek, Biochemistry, 2005, 44 (36), 12077-12085. [Full Paper]
    52. "Selective detection of catecholamines by synthetic receptors embedded in chromatic polydiacetylene vesicles" Sofiya Kolusheva, Oliver Molt, Michael Herm, Thomas Schrader, Raz Jelinek, J. Am. Chem. Soc., 2005, 127, 10000-10001. [Full Paper]
    53. "Temperature dependence of the organization and molecular interactions within phospholipid / diacetylene Langmuir films", F. Gaboriaud, R. Volinsky, A. Berman, R. Jelinek, J. Coll. Interface Sci., 2005, 287, 191-197. [Full Paper]
    54. "Membrane interactions of host defense peptides studied in model systems". R. Jelinek, S. Kolusheva, Curr. Prot. Pep. Sci., 2005, 6, 103-114. [Full Paper]
    55. Visualization of membrane processes in living cells by surface-attached chromatic polymer patches, Z. Orynbayeva, S. Kolusheva, E. Livneh, A. Lichtenshtein, I. Nathan,R. Jelinek, Angew. Chem. Intl. Ed., 2005, 44, 1092-1096 (designated a Very Important Paper [VIP]).
    56. “Microscopic visualization of alamethicin incorporation into model membrane monolayers”, R. Volinsky, S. Kolusheva, A. Berman, R. Jelinek, Langmuir, 2004, 20,, 11084-11091. [Full Paper]
    57. “Carbohydrate biosensors” R. Jelinek, S. Kolusheva, Chem. Rev., Chem. Rev. 2004, 104, , 5987-6015. [Full Paper]
    58. “Structure-Activity Determinants in Paneth Cell ±-Defensins: Loss-of-function in Mouse Cryptdin-4 by Charge-reversal at Arginine Residue Positions”, H. Tanabe, X. Qu, J. Cummings, S. Kolusheva, C. S. Weeks, K. B. Walsh, R. Jelinek,T. K. Vanderlick, M. E. Selsted, and A. J. Ouellette, J. Biol. Chem. 2004, 279, 11976-11983. [Full Paper]
    59. “Membrane binding and permeation by indolicidin analogs studied by a biomimetic lipid/polydiacetylene vesicle assay”, R. Halevy, A. Rozek, S. Kolusheva, R.E. Hancock, R. Jelinek, Peptides. 2003, 24, 1753-1761. [Full Paper]
    60. “Quantitative interactions between Cryptdin-4 amino terminal variants and membranes”, D.P. Satchell, T. Sheynis, J. Cummins, T.K. Vanderlick, R. Jelinek, A. Ouellette, Peptides. , 2003, 24, 1795-1805.
    61. “Bilayer localization of membrane-active peptides studied in bio-mimetic vesicles by visible and fluorescence spectroscopies”, T. Sheynis, J. Sykora, A. Benda, S. Kolusheva, M. Hof, R. Jelinek, Eur. J. Biochem., 2003, 270, 4478-4487. [Full Paper]
    62. “The human islet amyloid polypeptide forms transient membrane-active protofilaments”, Y. Porat, S. Kolusheva, R. Jelinek, E. Gazit., Biochemistry, 2003, 42, 10971-10977. [Abstract][Full Paper]
    63. “Lipid binding and membrane penetration of polymyxin B nona-peptide derivatives: significance of LPS binding and effects of a hydrophbic side residue”, M. Katz, H. Tsubery, M. Fridkin, S. Kolusheva, A. Shames,R. Jelinek, Biochem. J., 2003, 375, 405-413. [Abstract][Full Paper]
    64. "Detection and analysis of membrane interactions by a biomimetic colorimetric lipid/polydiacetylene assay", S. Rozner, S. Kolusheva, Z. Cohen, W. Dowhan, J. Eichler, R. Jelinek, Analytical Biochemistry, 2003, 319, 96-104. [Full Paper]
    65. "Interactions of Mouse Paneth Cell a- Defensins and a-Defensin Precursors with Membranes: Prosegment Inhibition of Peptide Association with Biomimetic Membranes" D.P. Satchell, T. Sheynis, Y. Shirafuji, S. Kolusheva, A. Ouellette, R. Jelinek, J. Biol. Chem., 2003, 278(16), 13838-13847.[Abstract][Full Paper]
    66. "Bio-mimetic lipid/polymer colorimetric membranes: Molecular and cooperative properties" S. Kolusheva, E. Wachtel, R. Jelinek, J. Lipid Research , 2003,44, 65-71.[Abstract][Full Paper]
    67. "Morphology and Organisation of Phospholipid/Diacetylene Langmuir Films Studied by Brewster Angle Microscopy and Fluorescence Microscopy". R. Volinsky, F. Gaboraiaud, A. Berman, ", R. Jelinek, J. Phys. Chem B., 2002, 106, 9231-9236[Abstract][Full Paper]
    68. "Mode of membrane interaction and structure in micelles of a short a-helical lytic peptide and its diastereomer determined by NMR, FTIR, and fluorescence spectroscopy". Z. Oren, J. Ramesh, D. Avrahami, N. Suryaprakash, Y. Shai, R. Jelinek. Eur. J. Biochem. 2002, 269: 3869-3880.[Full Paper]
    69. "Polymerized lipid vesicles as colorimetric biosensors for biotechnological applications", R. Jelinek, S. Kolusheva, Adv. Biotech., 2001, 19, 1-10.[Abstract]
    70. "A new colorimetric assay for studying and rapid screening of membrane penetration enhancers", D. Evrard, E. Touitou, S. Kolusheva, Y. Fishov, R. Jelinek. Pharm. Res., 2001, 18, 943-949. [Abstract][Full Paper]
    71. "Organization and structural properties of Langmuir films composed of conjugated polydiacetylene and phospholipids", F. Gaboriaud, R. Golan, R. Volinsky, A. Berman, R. Jelinek, Langmuir, 2001, 17, 3651-3657. [Abstract][Full Paper]
    72. "Rapid colorimetric detection of antibody-epitope recognition at a bio-mimetic membrane interface", S. Kolusheva, R. Kafri, M. Katz, R. Jelinek, J. Am. Chem. Soc., 2001, 123, 417-422. [Abstract] [Full Paper]
    73. "Peptide-membrane interactions studied by a new phospholipid/polydiacetylene colorimetric vesicle assay", S. Kolusheva, T. Shahal, R. Jelinek, Biochemistry, 2000, 39, 15851-15859. [Abstract] [Full Paper]
    74. "Colorimetric sensors for drug discovery and biomedical diagnostics", R. Jelinek, Drug Development Res., 2000, 50, 497-501. [Abstract]
    75. "Identification of Heroin in Street Doses Using 1D-TOCSY Nuclear Magnetic Resonance", N. Suryaprakash, M. Azoury, Z. Goren, R. Jelinek, J. Forensic Sci., 2000, 45, 963-967.
    76. "Cation-selective color sensors composed of ionophore - phospholipid - polydiacetylene mixed vesicles", S. Kolusheva, T. Shahal, R. Jelinek, J. Am. Chem. Soc., 2000, 122, 776-780. [Abstract] [Full Paper]
    77. "A colorimetric assay for rapid screening of anti-microbial peptides", S. Kolusheva, L. Boyer, R. Jelinek, Nature Biotechnology, 2000, 18, 225-227. [Abstract]
    78. Induced color change of conjugated polymeric vesicles by interfacial catalysis of phospholipase A 2, S.Y. Okada, R. Jelinek, D.H. Charych, Angew. Chemie, Intl. Ed. Eng., 1999, 38, 655-659.