Professor
Abraham H. Parola
Carol and Barry
Kaye Chair in Applied Science
Department of
Chemistry,
The Faculty of
Natural Sciences
Ben-Gurion
University,
P.O.
Box 653, Beer Sheva, Israel, 84105.
Tel: 972 8 647
2454 mobile: 972 52 8 795945
Fax: 972 8 6472943
Research Interests:
1. Membrane
dynamic changes associated with viral, chemical and electromagnetic cell
transformation and malignancy.
2. Adenosine deaminase (ADA) and adenosine deaminase
complexing protein (ADCP = CD26 = DPPIV) in cell
transformation: biophysical manifestation of membrane dynamics; reconstitution
in liposomes; effect of lipid composition, cholesterol and phase transition
on ADA activity; spectroscopic
deciphering of passive modulation, site
accessibility and hydrophobic mismatching models.
3. Protein-drug
interaction: fibroblast growth factor-2 (bFGF) and
the antiangiogenic drug Suradista.
4. Membrane
dynamics, cellular signaling and ciliary
motion.
5. Bacterial
cell cycle and the transertion model: DnaA and membrane domains.
6. Protein-protein interactions: effect of cold
inactivation on the quaternary structure of tryptophanase; point mutations, x-ray crystallography structure
determination; quorum sensing and biofilm formation; searching for a new generation of antibiotics
7. Free
radicals and bioelectromagnetics; do high voltage
wire lines cause cancer?
8. Programmed
cell death: apoptosis, necrosis and autophagy.
9. Protective
effect of humanin and Its derivatives against
necrotic cell death
10.
Diagnostics:
a. Fluorescence
immunoassays
b. Non-invasive
determination of fetal lung maturity
c. Development
and design of archetype equipment for the detection of drugs in body fluids
without reagents utilizing time resolved laser spectroscopy; 3D and synchronous
fluorescence spectra
d. resolved
laser spectroscopy; 3D and synchronous fluorescence spectra
e. Homeland
security: detection of poisons in water resources
f. Development
of a fluorescence assay for Interferon
Spectrofluorometry is the major method used in the above: single photon correlation and multifrequency phase modulation for lifetime, anisotropy decay and energy-transfer studies;
fluorescent affinity labels; fluorescent probes.