Dr. Noam Zilberberg:  Publications 


(a) Chapters in Collective Volumes - Conference Proceedings

  1. Gurevitz, M., Zilberberg, N., Urbach, D., Gordon, D., Zlotkin, E. & Chejanovsky,N. (1995) Alpha scorpion neurotoxins and baculoviruses: A working model for the design of novel selective insecticides. In: Bielefelder Okologische Beitrage, Bielefeld, Germany, pp. 25-41

  2. Gurevitz, M., Zilberberg, N., Urbach, D., Froy, O., Zlotkin, E., Hammock, B. D., Herrmann, R., Moskowitz, H. & Chejanovsky, N. (1996) Utilization of scorpion insecticidal neurotoxins and baculoviruses for the design of novel selective biopesticides. In: Modern Agriculture and the Environment (D. Rosen & E. Tel-Or, Eds.), Kluwer Academic Publ., pp. 81-96.

  3. Gurevitz, M., Froy, O., Zilberberg, N., Shaanan, B., Adams, M. E., Anglister, J., Pelhate, M., Chejanovsky, N. & Gordon, D. (1999) Sodium channel modulators from scorpion venoms: Structure-activity relationship and application. In: Progress in Neuropharmacology and Neurotoxicology of Pesticides and Drugs (D. Beadle, ed.) Oxford, UK, pp. 67-80

  4. Gurevitz, M., Froy, O., Zilberberg, N., Turkov, M., Strugatsky, D., Vilunsky, R., Gilles, N., Anglister, J., Shaanan, B., Pelhate, M., Stankiewicz, M., Adamas, M. E. & Gordon, D. (2002) Diversification of toxic sites on a conserved protein scaffold: a scorpion recipre for survival. In: Perspectives in Molecular Toxinology (Menez, A., Ed.) Wiley and Sons, Chichester, UK. In press.

(b) Refereed Articles in Scientific Journals

  1. Gurevitz, M., Zlotkin, E. & Zilberberg, N. (1990) Characterization of the transcript for a depressant insect selective neurotoxin gene with an isolated cDNA clone from the scorpion Buthotus judaicus. FEBS Lett. 269:229-232.

  2. Zilberberg, N., Zlotkin, E. & Gurevitz, M. (1991) The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus. Toxicon 29:1155-1158.

  3. Gurevitz, M., Urbach, D., Zlotkin, E. & Zilberberg, N. (1991) Nucleotide sequence and structure analysis of a cDNA encoding an alpha insect toxin from the scorpion Leiurus quinquestriatus hebraeus. Toxicon 29:1270-1272.

  4. Zilberberg, N., Zlotkin, E. & Gurevitz, M. (1992) Molecular analysis of cDNA and transcript encoding the depressant insect neurotoxin of the scorpion Leiurus quinquestriatus hebraeus. Insect Biochem. Molec. Biol. 22:199-203.

  5. Zilberberg, N. & Gurevitz, M. (1993) Rapid isolation of full length cDNA clones by "inverse PCR": Purification of a scorpion cDNA family encoding -neurotoxins. Anal. Biochem. 209:203-205.

  6. Gurevitz, M. & Zilberberg, N. (1994) Advances in molecular genetics of scorpion neurotoxins. J. Toxicol. - Toxin Rev. 13:65-100.

  7. Chejanovsky, N., Zilberberg, N., Rivkin, H., Zlotkin, E. & Gurevitz, M. (1995) Baculovirus directed expression of a functional alpha scorpion neurotoxin specific against insects in Spodoptera frugiperda insect cells and in Heliothis larvae. FEBS Lett. 376:181-184

  8. Zilberberg, N., Gordon, D., Zlotkin, E., Pelhate, M., Norris, T., Adams, M. E. & Gurevitz, M. (1996) Functional expression and genetic alteration of an alpha scorpion neurotoxin. Biochemistry 35:10215-10222.

  9. Tugarinov, V., Kustanovitz, I., Zilberberg, N., Gurevitz, M. & Anglister, Y. (1997) Solution structures of a highly insecticidal recombinant scorpion alpha-toxin and a mutant with increased activity. Biochemistry. 36:2414-2424.

  10. Turkov, M., Rashi, S., Zilberberg, N., Gordon, D., Ben Khalifa, R., Stankiewicz, M., Pelhate, M. & Gurevitz, M. (1997) In vitro folding and functional analysis of an anti-insect selective scorpion depressant neurotoxin produced in Escherichia coli. Ptot. Express. Purific. 10:123-131.

  11. Zilberberg, N., Froy, O., Cestele, S., Loret, E., Arad, D., Gordon, D. & Gurevitz, M. (1997) Identification of structural elements of a scorpion alpha-neurotoxin important for receptor site recognition. J. Biol. Chem. 272:14810-14816.

  12. Benkhalifa, R., Stankiewicz, M., Lapied, B., Turkov, M., Zilberberg, N., Gurevitz, M., & Pelhate, M. (1997) Refined electrophysiological analysis suggests that scorpion depressant neurotoxins are sodium channel openers rather than blockers. Life Sci. 61:819-830.

  13. Gurevitz, M., Froy, O., Zilberberg, N., Turkov, M., Strugatsky, D., Gershburg, E., Lee, D., Adams, M.E., Tugarinov, V., Anglister, J., Shaanan, B., Loret, E., Stankiewicz, M., Pelhate, M., Gordon, D. & Chejanovsky, N. (1998) Sodium channel modifiers from scorpion venom: Structure-activity relationship, mode of action and application. Toxicon 36:1671-1682

  14. Froy, O., Sagiv, T., Poreh, M., Urbach, D., Zilberberg, N. & Gurevitz, M. (1999) Dynamic diversification from a putative common ancestor of scorpion toxins affecting sodium, potassium and chloride channels. J. Mol. Evol. 48:187-196

  15. Froy, O., Zilberberg, N., Gordon, D., Turkov, M., Gilles, N., Stankiewicz, M., Pelhate, M., Loret, E., Oren, D., Shaanan, B. & Gurevitz, M. (1999) The putative bioactive surface of insect-selective scorpion excitatory neurotoxins. J. Biol. Chem. 274: 5769-5776

  16. Froy, O., Zilberberg, N., Chejanovsky, N., Anglister, J., Loret, E., Shaanan, B., Gordon, D. & Gurevitz, M. (2000) Scorpion neurotoxins: Structure/function relationships and application in agriculture. Pest. Manag. Sci. 56: 472-474

  17. Zilberberg, N., Ilan, N., Gonzalez-Colaso, R. & Goldstein S. A. N. (2000) Opening and closing of KCNKO potassium leak channels is tightly regulated. J. Gen. Physiol. 116:721-734

  18. Goldstein, S. A. N., Bockenhauer, D., O'Kelly. I & Zilberberg, N. (2001) Potassium leak channels and the KCNK family of two-P-domain subunits. Nature Rev. Neurosci. 2:175-184.

  19. Bockenhauer, D., Zilberberg, N. & Goldstein, S. A. N. (2001) KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nature Neurosci. 4:486-491.

  20. Lopes, C. M. B., Zilberberg, N. & Goldstein S. A. N. (2001) Block of Kcnk3 by protons: evidence that 2-P-domain potassium channel subunits function as homodimers. J. Biol. Chem. 276:24449-24452

  21. Zilberberg, N., Ilan, N. & Goldstein, S. A. N. (2001) KCNKO: Opening and closing the 2-P-domain potassium leak channel entails "C-type" gating of the outer pore. Neuron. 32:635-648

  22. O'Kelly, I., Butler, M. H., Zilberberg, N., Goldstein, S. A. N. (2002) Forward transport: 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals. Cell 111:577-588 8.

Lectures and Presentations at Meetings and Invited Seminars

(a) Presentation of Papers at Conferences/Meetings

  1. Zilberberg, N., Urbach, D. & Gurevitz, M. (1991) Utilization of scorpion insect selective neurotoxins for the future design of insecticides. Ann. Meet. Isr. Plant Mol. Biol., Rehovot, Israel.

  2. Zilberberg, N., Urbach, D. & Gurevitz, M. (1991) Utilization of scorpion insect selective neurotoxins for the future design of insecticides. Frontiers of Biotechnology in Agriculture, Ginosar, Israel

  3. Zlotkin, E., Zilberberg, N., Gordon, D. & Gurevitz, M. (1992) An insect specific alpha scorpion toxin: Chemistry, action, cloning and expression. First Ann. Meet. Israel Soc. Neuroscience, Eilat, Israel.

  4. Gurevitz, M., Zilberberg, N., Gordon, D., Zlotkin, E. & Chejanovsky, N. (1993) Scorpion neurotoxins as models for the design of insecticides and for improving the insecticidal efficacy of baculoviruses. First Natl. Cong. Peptides and Drugs Release, Jerusalem, Israel

  5. Chejanovsky, N., Gurevitz, M., Zilberberg, N. & Zlotkin, E. (1993) Baculovirus directed expression of the insect-selective alpha neurotoxin Lqh IT. IXth Intern. Cong. Virology, Glasgow, Scotland.

  6. Gurevitz, M., Zilberberg, N., Zlotkin, E., Gordon, D. & Chejanovsky, N. (1993) Structure-activity relationship of scorpion neurotoxins and their utilization for the design of biopesticides. XI European Meet. IST, Arezzo, Italy.

  7. Zilberberg, N., Gordon, D., Zlotkin, E., Pelhate, M., Chejanovsky, N. & Gurevitz, M. (1994) Expression of an active alpha scorpion neurotoxin using Escherichia coli cells and lepidopterous larvae. Structure-activity relationship and future applications. 11th World Cong. on Animal, Plant and Microbial toxins, Tel-Aviv, Israel, p. 39.

  8. Chejanovsky, N., Zilberberg, N., Rivkin, H., Zlotkin, E. & Gurevitz, M. (1994) Baculovirus-directed expression of an alpha anti-insect neurotoxin derived from the Israeli yellow scorpion. 11th World Cong. on Animal, Plant and Microbial toxins, Tel-Aviv, Israel, p. 40.

  9. Gurevitz, M., Zilberberg, N., Urbach, D., Zlotkin, E. & Chejanovsky, N. (1994) Utilization of scorpion insecticidal neurotoxins for the design of novel selective biopesticides. Modern Agriculture and the Environment, Rehovot, Israel, p. A17.

  10. Gurevitz, M., Zilberberg, N., Turkov, M., Froy, O., Rashi, S., Zlotkin, E., Arad, D. & Chejanovsky, N. (1995) Utilization of anti-insect selective neurotoxins from scorpions for the design of novel biopesticides. Ann. Meet. Israel Plant Mol. Biol., Haifa, Israel.

  11. Chejanovsky, N., Zilberberg, N., Rivkin, H., Zlotkin, E. and Gurevitz, M. (1995) Baculovirus- directed expression of a functional alpha anti-insect neurotoxin derived from the Israeli yellow scorpion. F.I.S.E.B., Eilat, Israel. p. 41.

  12. Gurevitz, M., Froy, O., Zilberberg, N., Turkov, M., Tugarinov, V., Anglister, J., Loret, E., Gordon, D. & Chejanovsky, N. (1997) Structure-activity relationship of insecticidal scorpion neurotoxins and their use for the design of novel insecticides. 5th Internl. Conf. on Invertebrate Neurochemistry & Neurophysiology - ICINN, Eilat, Israel, p. 86.

  13. Guveritz, M., Froy, O., Zilberberg, N., Turkov, M., Loret, E., Gordon, D. & Chejanovsky N. (1998) Structure-activity relationship of insecticidal scorpion neurotoxins and their use for the design of novel insecticides. 12th World Congress on Animal, Plant and Microbial Toxins, Cuernavaca, Mexico. Toxicon 36(9), 1223.

  14. Froy, O., Zilberberg, N., Chejanovsky, N., Anglister, J., Loret, E., Shaanan, B., Gordon, D. and Gurevitz, M. (1998) Scorpion neurotoxins: structure/function relationships and application in agriculture. Nerotox 98- Progress in Neuropharmacology and Neurotoxicology of Pesticides and Drugs. SCI, Oxford, UK.

  15. Zilberberg, N. & Goldstein, S. A. N. (1998) Does zinc reveal a closed state in cloned d-ORK1, the K+-selective leak channel with two P domains from Drosophila melanogaster excitable cells? Biophysical Society meeting, Biophys. J. 74(2 PART 2), A205.

  16. Ilan, N., Zilberberg, N., Gonzalez-Colaso, R. & Goldstein, S. A. N. (1999) Molecular dissection and single-channel analysis reveals gating of an open-rectifier (leak) K+ channel by its cytoplasmic tail. Biophysical Society meeting, Biophys. J. 76(1 PART 2), A411.

  17. Zilberberg, N., Ilan, N., Gonzalez-Colaso, R. & Goldstein, S. A. N. (2000) Closing of potassium-selective leak channels is tightly-regulated by phosphorylation. Biophysical Society meeting, Biophys. J. 78(1 Part 2).

  18. Zilberberg, N., Ilan, N. & Goldstein, S. A. N. (2001) Do 2 P domain leak channels gate by C-type inactivation? Biophysical Society meeting, Biophys. J. 80(1 Part 2), 183a.

  19. O'Kelly, I., Butler, M. H., Zilberberg, N., Goldstein, S. A. N. (2003) A general mechanism for forward transport of proteins subject to retention in endoplasmic reticulum via dibasic signals.Biophysical Society meeting, Biophys. J. 84(2 Part 2), 62a.

Last Updated: 20/12/2005