Dr. Yair Manor: Curriculum Vitae

 

1. PERSONAL DETAILS

Name:

Yair Manor

Date of Birth:

October 4, 1959, Rehovot, Israel

Military service: 

1/9/1977-1/6/1981

 Work:

Tel: 972-8-6461351; Fax: 972-8-6461353

 Home:

Nathan Hanavi, 8. Jerusalem

     

2. EDUCATION

1982-1984

B.Sc. -  Hebrew University, Biology

1983

Dean's Award

1984

Dean's Award 

1984-1986

B. Sc. -  Hebrew University, Computer Sciences

1987-1989

M.Sc. -  Hebrew University, NeurobiologyAdvisor: Dr. Idan Segev Thesis: "A Theoretical Analysis, with a Computer Simulation, of Action Potential Conduction in Bifurcating axons".

1989-1995

Ph.D.- Hebrew University, Neurobiology Advisors: Prof. Idan Segev and Yosef Yarom. Thesis: "Construction of an experimentally based neuronal network to explore the function of the inferior olive  nucleus".



3
. EMPLOYMENT HISTORY 

2002-present 

Senior Lecturer (Equiv. Assistant/Associate Professor) Life Sciences Department, Ben-Gurion University, Israel

1998-2002

Lecturer (equiv. Assistant Professor) Life Sciences Department, Ben-Gurion University, Israel

1995-1998

Post-Doctoral research Volen Center for Complex Systems, Brandeis University, USA

1993 (Summer)

Research Courtesy Associate Math Research Branch, NIDDK (at NIH), VA, USA.

1993-1995

Teaching Assistant Neurobiology Department, Hebrew University

1993-1995

Real Time Programmer Psychophysics Laboratory, Smith Institute, Hebrew University

1993-1995 

Applications Programmer Sackler Faculty of Medicine, Tel-Aviv University

1987

Teaching Assistant Computer Science Department, Hebrew University

1984-1986 

Lecturer - Programming Languages Programming Education Department, Hebrew University

1982 (Summer)

Project Biochemistry Department, Hebrew University

 

Professional activities

Courses taught

  1. Introduction to Animal Physiology, Undergraduate level, Ben-Gurion University, jointly with Profs. S. Silberberg and F. Libersat.

  2. Introduction to Neurobiology, Undergraduate level, Ben-Gurion University, jointly with Prof. F. Libersat.

  3. Laboratory in Animal Physiology, Undergraduate level, Ben-Gurion University, jointly with Profs. S. Silberberg, A. Sagi and F. Libersat.

  4. Neural Mechanisms of animal behavior, Undergraduate/Graduate level, Ben-Gurion University, jointly with Prof. F. Libersat.

  5. Advanced techniques in electrophysiology. Undergraduate level, Ben-Gurion University, jointly with Prof. F. Libersat

  6. Using MatLab to solve biological problems. Graduate level, Ben-Gurion University, jointly with Drs. C. Keasar and A. Bouskila

  7. Basic principles of function in nervous systems: Computational Neuroscience unit, Graduate level, Ben-Gurion University, jointly with Dr. D. Golomb.

  8. Neural Systems and Behavior, MBL, Woodshole (STG Cycle).

  9. Tutoring in Research Project. Undergraduate level, Ben-Gurion University 

  10. Tutoring in Instructive Reading. Undergraduate level, Ben-Gurion University 

  11. FORTRAN, PASCAL and C Programming for Natural Sciences, Hebrew University

  12. SPSS and SAS Programming for Social Sciences, Hebrew University

Membership in professional/scientific societies

1996-Present

American Society for Neuroscience

1998-Present

Israeli Society for Neuroscience

1998-Present

Zlotowski Center for Neuroscience

 

4. AWARDS, HONORS AND RESEARCH FELLOWSHIPS

 Honors and Awards

1995

Katzir-Katchalsky Award, Weizman Institute of Science

1997

John F. Perkins Award, American Physiological Society

2001

Bell and Murray Nathan Career Development Chair in Neurobiology

2003

Gruss-Lipper fellowship


5. SCIENTIFIC PUBLICATION

Chapters in collective volumes

  1. Segev,I. Rapp, M., Manor,Y. and Yarom,Y. (1991). Analog and digital processing in single nerve cells: dendritic integration and axonal propagation. In: Single Neuron Computation. Ch. 7., pp 173-198 (T. McKenna , J. Davis, S.F Zornetzer., Eds).

2. Manor,Y., Yarom,Y., Rinzel, J. and Segev, I. (1996) Subthreshold spontaneous oscillations in the inferior olive: an experimentally-based minimal, biophysical network model. In: Computational Neuroscience, pp 233-238, (J. M. Bower Ed.), Academic Press.

3. Nadim, F., Manor,Y., Abbott,L.F. and Marder,E. (1997) Strength and timing of graded synaptic transmission depend on frequency and shape of the presynaptic waveform minimal, biophysical network model-based. In: Trends in Research, 1997,pp. 19-22, (J.M. Bower, Ed.), Plenum Press, New-York and London,

4. Manor,Y., Nadim,F., Nusbaum, M.P. and Marder,E. (1997) Modeling the MCN1-activated gastric mill rhythm: the interaction between fast and slow oscillators. In: Trends in Research, 1997,pp. 391-394, (J. M. Bower, Ed.), Plenum Press, New-York and London.

5. Birmingham, J.T., Manor, Y., Nadim, F., Abbott, L.F., and Marder, E. (1998). An Empirical Model Describing the Dynamics of Graded Synaptic Transmission in the Lobster Pyloric Network. In :Computational Neuroscience: Trends in Research, 1998, ( J. M. Bower, Ed.) ,Plenum Press, New York and London.

6. Nadim, F., Manor, Y., Epstein, S., and Marder, E. (1998). Entrainment of a Slow Neuronal Oscillator by a Fast One. In: Computational Neuroscience: Trends in Research, (J. M. Bower, Ed.), Plenum Press, New York and London.

7. Manor, Y., Nadim, F., and Marder, E. (1998). Using the Dynamic Clamp Technique to Study Frequency Regulation of the Pyloric Rhythm. In: Computational Neuroscience: Trends in Research (J. M. Bower, Ed.), Plenum Press, NY.

* 8. Nadim, F., Manor, Y., Kopell, N., and Marder, E. (1998). A Synapse Acting as a Switch: A Role for Synaptic Depression of Graded Synapses. In: Annals of Biomedical Engineering, Gerald, Vol. 26, Supp.1, (M. Saider, Ed.).

* 9. Marder, E. Manor, Y. Nadim, F. Bartos, M. and Nusbaum, M.P. (1998). Frequency control of a slow oscillatory network by a fast rhythmic input: pyloric to gastric mill interactions in the crab stomatogastric nervous system. In: Neuronal Mechanisms for Generating Locomotor Activity. Ann. N. Y. Acad. Sci. (860), pp 226-238.

Refereed articles in scientific journals

1. Manor,Y., Gonczarowsky, Y. and Segev, I. (1991). Propagation of action potentials along axonal trees. Biophys. J. 60: 1-13.

2. Manor, Y., Koch, C. and Segev, I. (1991). The effect of geometrical irregularities on propagation delay in axonal trees. Biophys. J. 60: 14-26.

3. Manor, B., Rinzel, J., Segev, I. and Yarom, Y. (1997). Low Amplitude Oscillations in the Inferior Olive: A model based on electrical coupling of neurons with heterogeneous channel densities. J. Neurophysiol. 77: 2736-2752.

4. Manor, Y., Nadim, F., Abbott, L.F. and Marder, E. (1997). Temporal dynamics of graded synaptic transmission in the lobster stomatogastric ganglion. J. Neurosci. 17(14): 5610-5621.

5. Nadim, F., Manor, Y., Nusbaum, M.P. and Marder, E. (1998). Frequency regulation of a slow rhythm by a fast periodic input. J. Neurosci. 18(13): 5053-506.

6. Manor, Y., Nadim, F., Epstein, S., Ritt, J., Marder, E. and Kopell, N. (1999). Network oscillations generated by balancing graded asymmetric reciprocal inhibition in passive neurons. J. Neurosci. 19(7): 2765-2779.

7. Bartos, M., Manor, Y., Nadim, F., Marder, E. and Nusbaum, M.P. (1999). Coordination of Fast and Slow Rhythmic Neuronal Circuits. J. Neurosci. 19(15): 6650-6660.

8. Nadim, F., Manor, Y., Kopell, N. and Marder, E. (1999). Synaptic depression creates a switch that controls the frequency of an oscillatory circuit. Proc. Nat. Acad. Sci. 96:8206-8211.

9. Golowasch, J., Manor, Y. and Nadim, F. (1999). Recognition of slow processes in rhythmic networks. Trends in Neurosci. 22 (9):375-377.

10. Nadim, F. and Manor Y. (2000). The role of short-term synaptic dynamics in motor control. Curr. Opin. in Neurobiol., Vol 10 (6): 691-698.

11. Manor, Y., Chorev, E., Yarom, Y. and Kogan, E. (2000). To beat or not to beat: a decision taken at the network level. J. Physiol. (Paris), 94(5-6): 375-390.

12. Nadim, F. Manor, Y. and Bose, A. (2001). Control of network output by synaptic depression. Neurocomputing 38-40(1-4): 781-787.

13. Manor, Y. and Nadim, F. (2001). Frequency regulation demonstrated by coupling a model and a biological neuron. Neurocomputing 38-40 (1-4):269-278.

14. Bose, A., Manor, Y. and Nadim, F. (2001). Bistable oscillations arising from synaptic depression. SIAM Journal of Applied Mathematics. 62(2):706-727.

15. Manor, Y. and Nadim, F. (2001). Synaptic depression mediates bistability in neuronal networks with recurrent inhibitory connectivity. J. Neurosci.. 21(23):9460-9470.

16. Nadim, F. Booth, V. Bose, A. and Manor, Y. (2003). Short-term synaptic dynamics promote phase-maintenance in multi-phasic rhythms. Neurocomputing 52-54: 79-87

17. De Zeeuw, CI. Chorev, E. Devor, A. Manor, Y. Van Der Giessen, RS. De Jeu, MT, Hoogenraad, CC Bijman, J. Ruigrok, TJH. French, P. Jaarsma, D. Kistler, WM. Meier, C. Petrasch-Parwez, E. Dermietzel, R. Sohl, G. Gueldenagel, M. Willecke, K.and Yarom, Y. (2003) Deformation of Network Connectivity in the Inferior Olive of Connexin 36-Deficient Mice Is Compensated by Morphological and Electrophysiological Changes at the Single Neuron Level. J. Neurosci. 23(11):4700-4711.

18. Manor, Y. Bose, A. Booth, V. and Nadim, F. (2003). Contribution of Synaptic Depression to Phase Maintenance in a Model Rhythmic Network. J. Neurophysiol. ; 90: 3513-3528

19. Mamiya, A. Manor, Y. and Nadim F. (2003) Short-term dynamics of a mixed chemical and electrical synapse in a rhythmic network. J. Neurosci. 23(29): 9557-9564.

Published scientific reports and technical papers

Manor, Y. and Nadim, F. (1997) Dynamic synapse simulator for studying neuronal circuitry using LabWindows/CVI. In: Virtual Instrumentation in Education 1997, pp. 207-215, Ed. National Instruments.

Unrefereed professional articles and publications

Manor, Y. and Nadim F. (2001). Neurons and Neural Networks: Computational Models. In: Encyclopedia of Life Sciences, Macmillan Reference, Ltd. Accepted 23 October 2000, In Press.

Presentation of papers at conferences/meetings

1.Manor, Y. and Segev, I. (1989) Toward a state machine representation of axonal propagation. Israeli Assoc. Physiol., Jerusalem, Israel.

2.Manor, Y. and Segev, I. (1989). Computer study of propagation delays in axonal trees. Binational meeting Germany-Israel, Jerusalem, Israel.

3.Manor, Y. and Segev, I. (1990). Theoretical consequences of axonal inhomogeneities for the processing of action potentials in nerve cells. Eur. J. Neurosci., Supp. 3., Stockholm, Sweden.

4.Manor, Y., Segev, I. and Yarom, Y. (1991). Electrotonic coupling in inferior olive and its contribution to network activity. Soc. des Neurosciences, Arcachon, France.

5.Manor, Y., Segev, I. and Yarom, Y. (1992). The physiological consequences of electrotonic coupling in the inferior olive. Israeli. Soc. Neurosci., Eilat, Israel.

6. Manor, Y., Segev, I. and Yarom, Y. (1993). Point voltage clamp experiments in a network of coupled neurons: are they meaningful? Israeli Soc. Neurosci, Eilat, Israel.

7. Manor, Y., Segev, I., and Yarom, Y. (1994). A network model of electrically coupled neurons can explain the subthreshold oscillations in the inferior olive. Israeli Soc. Neurosci., Eilat, Israel.

8. Manor, Y., Yarom, Y., Rinzel, J. and Segev, I. (1995) Subthreshold oscillations in the inferior olive: a realistic network model. Comp. Neurosci., Monterey,USA.

 

9. Manor, Y., Yarom, Y., Rinzel, J. and Segev, I. (1995) A network model of electrically coupled neurons can explain the sub-threshold oscillations in the inferior olive. Soc. Neurosci., San Diego,USA.

10. Rinzel, J., Manor, Y., Yarom, Y. and Segev, I. (1996). Silent but heterogeneous neurons when gap junction coupled can oscillate collectively. Am. Math. Soc., Minneapolis, USA.

11. Nadim, F., Manor, Y., Nusbaum, M.P. and Marder, E. (1996). A model of the crab gastric mill rhythm: the interaction between a slow and a fast oscillatory neuronal network. Am. Math. Soc, Minneapolis,USA.

12. Nadim, F., Manor, Y., Coleman, M., Nusbaum, M.P. and Marder, E. (1996). The interaction between presynaptic inhibition and electrical coupling in the generation of the stomatogastric ganglion gastric mill rhythm. Comp. Neurosci., Boston,USA.

13. Manor, Y., Nadim, F., Sen, K., Abbott, L.F. Marder, E. (1996). Characterization of the dynamics of graded synaptic transmission in stomatogastric neurons. Comp. Neurosci., Boston,USA.

14. Nadim, F., Manor, Y., Abbott, L.F. and Marder, E. (1996). Temporal dynamics of graded synaptic transmissionin the lobster pyloric network. Soc. Neurosci., Washington DC, USA.

15. Manor, Y., Nadim, F., Marder, E., & Nusbaum, M.P. (1996). A model for the MCN1-activated gastric mill rhythm. Soc Neurosci., Washington DC, USA.

 

16. Nadim, F., Manor, Y., Nusbaum, M.P. and Marder, E (1997) The interplay of the slow MCN1-activated gastric mill rhythm and the fast pyloric oscillator in the stomatogastric ganglion of the crab. Comp. Neurosci., Big-Sky Montana, USA.

17. Manor, Y., Nadim, F., Abbott, L.F. and Marder, E. (1997) Using a computational model to study the dynamics of synaptic transmission netween neurons in the lobster pyloric network in an experimental setting. Comp. Neurosci., Big Sky Montana, USA

18. Epstein, S., Ritt, J., Manor, Y., Nadim, F., Marder, E. and Kopell, N. (1998). A novel mechanism of network oscillation based on asymmetric reciprocal inhibition. Soc. Neurosci., New-Orleans, USA

19. Nadim, F., Manor, Y., Kopell, N., Abbott, L.F. and Marder, E. (1998). The role of depression of a graded synapse in an oscillating network of neurons. Soc. Neurosc. New-Orleans, USA

20. Manor, Y., Nadim, F., Bartos, M., Marder, E. and Nusbaum, M.P. (1998) Dynamic regulation of motor pattern generation via disinhibition and neuromodulation. Soc. Neurosci., New-Orleans, USA.

21. Nadim, F., Manor, Y., Kopell, N. and Marder, E. (1998). Frequency regulation by a synapse acting as a switch: a role for synaptic depression of graded transmission. Comp. Neurosci. Santa-Barbara, USA

22. Manor, Y., Nadim, F. and Nusbaum, M.P.(1998). Israeli Societies for Experimental Biologists (Ilanit) , Eilat, Israel.

23. Manor, Y., Nadim, F. and Marder, E. (1998). Israeli Soc. Physiol & Pharmacol., Maale Hahamisha, Israel.

24. Bose, A., Manor, Y. and Nadim, F. (2000). Control of network output by synaptic depression. Comp. Neurosci., Bruges, Belgium.

25. Manor, Y. and Nadim, F. (2000). Synaptic depression is used to switch between disctinct oscillatory states in circuits with recurrent inhibition. Comp. Neurosci., Bruges, Belgium.

26. Wood, D.E., Manor, Y., Nadim, F. and Nusbaum, M.P. (2000) Flexibility in intercircuit interactions influences motor pattern generation. Soc. Neurosci., New-Orleans, USA.

27. Mamiya, A., Wood, D.E., Nusbaum, M.P., Manor, Y. and Nadim, F. (2000). Shifting the locus of control between fast and slow rhythms in a network model. Soc. Neurosci., New-Orleans, USA.

 

28. Nadim, F. , Manor, Y. and Bose, A. (2000). Synaptic depression promotes bistability in an excitatory-inhibitory network. Soc. Neurosci., New-Orleans, USA.

29. Manor, Y. and Nadim, F. (2000). When two depressing synapses are better than a single one. Soc. Neurosci., New-Orleans, USA.

30. Chorev, E., Yarom, Y. and Manor, Y. (2000). The dynamic state of olivary neurons depends on their channel densities Isr. Soc. Neurosci., Eilat, Israel.

* 31. Chorev, E. Yarom, Y. and Manor, Y. (2001). Heterogeneity in electrical behavior of neurons from the inferior olive. Isr. Soc. Neurosci., Eilat, Israel.

* 32. Manor. Y. Chorev, E. and Yarom, Y. (2001). Heterogeneity in the functional state of olivary neurons revealed by dynamic clamp. Soc. Neurosci. , San-Diego, USA.

* 33. Atamturktur, S. Mamiya, A. Manor, Y. Nadim, F. (2001). Synaptic dynamics regulate the pyloric network period. Soc. Neurosci. , San-Diego, USA.

* 34. Nadim, F. Bose, A. Booth, V. and Manor, Y. (2001). Synaptic depression promotes phase constancy. Soc. Neurosci. , San-Diego, USA.

* 35. Mamiya, A. Manor, Y. and Nadim, F. (2001). A synapse that dynamically switches from inhibitory to excitatory. Soc. Neurosci. , San-Diego, USA.

* 36. Nadim, F. Booth, V. Bose, A. and Manor, Y. (2002). Short-term synaptic dynamics promotes phase maintenance in multi-phasic rhythms. Computational Neurosciences, Chicago, USA.

* 37. Manor, Y. Booth, V. Bose, A. and Nadim, F. (2002). Short-term synaptic depression promotes phase maintenance in oscillatory networks. 3rd Forum of European Neurosciences, Paris, France.

*38. Manor, Y. M. Brodt and A. Medini (2002). The modulation of frequency-dependence of synaptic transmission in the pyloric circuit of Homarus americanus and its implication to function. Soc. Neurosci., Orlando, USA.

*39. Chorev, E. Manor, Y. and Yarom, Y. (2002) Electrical coupling can induce oscillation in quiescent olivary neurons: a dynamic clamp study. Soc. Neurosci., Orlando, USA.

*40. Chorev, E. Devor, A. Manor, Y. de Zeeuw, C. and Yarom, Y. (2002) Knockout of gap junctions in the inferior olive "knocks-in" compensatory mechanisms that allows for the production of oscillations in single olivary neurons. Isr. Soc. Neurosci,, Eilat, Israel.

 Seminars at universities and institutions.

*1. 1998- Oscillations generated by balancing reciprocal inhibition in passive neurons. , GABA mini-course, Ben-Gurion university, Israel.

*2. 1999- Small but complex networks. Center for neural computation, Hebrew University, Jerusalem, Israel.

*3. 1999- Physiology of the olivo-cerebellar system. Processing in the brain, Ecole de physiques, les Houches, France.

*4. 2000- The mechanism of subthreshold oscillations in the inferior olive. Mathematical research, NJIT, Newark, USA.

5. 2002- The role of synaptic depression in shaping the output of small neuronal networks. Gatsby, University College of London, UK.

6. 2002- The role of synaptic depression in shaping the output of small neuronal networks. Bar-Ilan University, Neuroscience Dept.

7. 2003- The role of synaptic depression in shaping the output of small neuronal networks. Hebrew University, Medic. School, Physiology Dept. 

8. 2003- The role of synaptic depression in shaping the output of small neuronal networks. Weizmann Institute, Neurobiol. Dept.

 

6. RESEARCH GRANTS

1. 1998-2001: Binational United-States/Israel (97-0074). Grantees: Dr. Yair Manor and Prof. Michael P. Nusbaum. Title of research: "Regulation of a slow rhythm by fast neuronal oscillator". Period of grant: 1/9/1998-31/8/2001. Annual amount: 33,000$. Total amount: 100,000$.

* 2. 1999-2002: Israel Academy of Sciences (31/99). Grantees: Dr. Yair Manor. Title of research: "The role of synaptic depression in frequency regulation of oscillatory neuronal networks". Period of grant: 1/10/1999 - 30/9/2002. Annual amount: 35,000 $. Total amount: 130,000$.

3. 2002-2006: Binational United-States/Israel (2001-0038). Grantees: Dr. Yair Manor, Prof. F. Nadim and Prof. E. Marder . Title of research: "Mechanisms of Dose- and State-dependence of neuromodulation". Period of grant: 1/9/2002-31/8/2006. Annual amount: 50,000$. Total approximated amount: 200,000$.

4. 2002-2003: Seed (BGU University) Grant. Grantee: Dr. Yair Manor. Title of research: "Bistability in neuronal networks mediated by synaptic depression". Total amount: 20,000 NIS.

5. 2003: Gruss-Lipper fellowship, MBL . Grantee: Dr. Yair Manor. Title of research: "State dependence of neuromodulation". Total Amount: 19,000$



7. RESEARCH STUDENTS

Miriam Brodt, M.Sc. degree (2001-2003)

Edith Chorev, Ph. D. degree, (jointly with Prof. Y. Yarom from the Dept. of Neurobiology, Hebrew University) (1998-).

Inbar Saraf, M. Sc. (2003-)


8. PRESENT ACTIVITIES

Research in Progress

"Mechanisms of Dose- and State-dependence of neuromodulation ". Other participants: Prof. Farzan Nadim, Rutgers University & NJIT; Prof. Eve Marder, Brandeis University. Expected date of completion: 2006.

"Unravelling the mechanism of the olivo-cerebellar clock". Other participants: Prof. Y. Yarom, Hebrew University. Expected date of completion: 2004.

9. Additional information

  1. I developed, jointly with Prof. Avishai Henik from Behavioral Sciences at Ben-Gurion University, a new undergraduate program called "Biology-Psychology".

  2. Reviewers of different leading journals, such as: J. Neurophys , J Neurosci.

  3. Peer-reviewer for American NSF and Israeli ISF grant proposals.

  4. Webmaster of the Life Sciences Department site at Ben-Gurion University.

  5. Member of the departmental teaching committee at Ben-Gurion University.

  6. Activities for the community: Lecture, Brain week 2003


Last Updated: 20/12/2005