NETTA VIDAVSKY
Research
The interactions between cancer cells and calcium-containing minerals
We synthesize mineral particles that mimic cancer microcalcifications commonly found in breast and thyroid cancers, and investigate links between their physicochemical properties and cellular behavior. In this in vitro project, we use engineered tumor models and a library of mineral particles, including calcium phosphates and calcium oxalates, to explore how mineral properties influence cellular uptake and response across different cell types.
The relationship between the crystal properties of cancer microcalcifications and disease progression
Using clinical samples of breast and thyroid cancer tissues, we characterize microcalcification composition, structure, and properties using imaging, spectroscopy, and diffraction techniques and correlate them with prognosis and diagnosis. This project may contribute to the development of improved diagnostics and therapeutic strategies. The thyroid study is carried out in collaboration with Soroka Medical Center.
Exploring Extracellular Matrix (ECM)-mineral-cell interactions using modular in vitro systems
We investigate the dynamic interplay between minerals, ECM-mimicking hydrogels, and cancer cells or fibroblasts. This project focuses on understanding how mineral properties and hydrogel structure influence these interactions, providing insights into cellular behavior and matrix remodeling. We develop modular crystal-cell-ECM systems that serve as models for biomineralization-related diseases in soft tissues and for potential biomedical applications.
